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Tbio
DDX31
Probable ATP-dependent RNA helicase DDX31

Protein Summary
Description
Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310532
  • ENSP00000310539
  • ENSG00000125485
  • ENST00000372153
  • ENSP00000361226
  • ENST00000372159
  • ENSP00000361232
  • ENST00000480876
  • ENSP00000479697

Symbol
  • PPP1R25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.94
protein domain
0.92
transcription factor binding site profile
0.79
histone modification site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (325)
LPO
Tbio
Family:  Enzyme
Novelty:  0.00220929
p_int:  1
Score:  0.189
Data Source:  BioPlex,STRINGDB
LEG1
Tbio
Novelty:  0.04089511
p_int:  0.999999967
p_ni:  1.5e-8
p_wrong:  1.8e-8
Score:  0.16
Data Source:  BioPlex,STRINGDB
OPRPN
Tdark
Novelty:  0.01627984
p_int:  0.99999985
p_wrong:  1.49e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CP
Tbio
Novelty:  0.00103285
p_int:  0.999999838
p_ni:  1.49e-7
p_wrong:  1.3e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
IGLC2
Tdark
p_int:  0.999999803
p_ni:  1.46e-7
p_wrong:  5.1e-8
Data Source:  BioPlex
HP
Tbio
Novelty:  0.00016649
p_int:  0.999999799
p_ni:  1.98e-7
p_wrong:  3e-9
Data Source:  BioPlex
IGHM
Tbio
p_int:  0.999999672
p_ni:  3.28e-7
Data Source:  BioPlex
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.99999956
p_ni:  3.41e-7
p_wrong:  9.8e-8
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.999999115
p_ni:  8.76e-7
p_wrong:  9e-9
Data Source:  BioPlex
IGHA2
Tbio
p_int:  0.999998429
p_ni:  0.000001503
p_wrong:  6.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
77.9
self reported educational attainment
2
2
2
68.7
biological sex
1
1
1
37.3
age at menopause
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
77.9
self reported educational attainment
2
68.7
biological sex
1
37.3
age at menopause
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 31
VGNC:13868
464816
Macaque
DEAD-box helicase 31
714800
Mouse
MGI:2682639
227674
Rat
RGD:1304895
311835
Horse
DEAD-box helicase 31
VGNC:17090
100069463
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 31
Macaque
DEAD-box helicase 31
Mouse
Rat
Horse
DEAD-box helicase 31
Publication Statistics
PubMed Score 0.49
PubMed score by year
PubTator Score 0.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title