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Tbio
DDX28
Probable ATP-dependent RNA helicase DDX28

Protein Summary
Description
Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332395
  • ENSP00000332340
  • ENSG00000182810

Symbol
  • MDDX28
  • MDDX28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
virus perturbation
0.94
interacting protein
0.81
transcription factor binding site profile
0.8
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.09   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.09   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (276)
RPUSD4
Tdark
Family:  Enzyme
Novelty:  0.39210095
p_int:  0.999764421
p_ni:  0.000235571
p_wrong:  9e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
METAP2
Tchem
Family:  Enzyme
Novelty:  0.00570955
p_int:  0.998678105
p_ni:  0.001321895
Score:  0.201
Data Source:  BioPlex,STRINGDB
TRUB2
Tdark
Family:  Enzyme
Novelty:  0.4130414
p_int:  0.993332265
p_ni:  0.006667735
Score:  0.897
Data Source:  BioPlex,STRINGDB
PTCD1
Tdark
Novelty:  0.17182155
p_int:  0.991013588
p_ni:  0.008986412
Score:  0.789
Data Source:  BioPlex,STRINGDB
MTERF3
Tdark
Novelty:  0.06316581
p_int:  0.970896368
p_ni:  0.029103632
Score:  0.813
Data Source:  BioPlex,STRINGDB
MALSU1
Tbio
Novelty:  0.38026342
p_int:  0.958705397
p_ni:  0.041294572
p_wrong:  3.1e-8
Score:  0.799
Data Source:  BioPlex,STRINGDB
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
p_int:  0.95813719
p_ni:  0.04186281
Score:  0.666
Data Source:  BioPlex,STRINGDB
MCAT
Tbio
Family:  Enzyme
Novelty:  0.00600508
p_int:  0.944553145
p_ni:  0.055446855
Score:  0.791
Data Source:  BioPlex,STRINGDB
UBR5
Tbio
Family:  Enzyme
Novelty:  0.00608732
p_int:  0.933824916
p_ni:  0.066175084
Score:  0.239
Data Source:  BioPlex,STRINGDB
NGRN
Tbio
Novelty:  0.11162143
p_int:  0.933223614
p_ni:  0.066775388
p_wrong:  9.98e-7
Score:  0.609
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
14
23
10
99.1
apolipoprotein A 1 measurement
1
4
4
97.4
red blood cell density measurement
1
1
1
82.3
mean corpuscular volume
1
1
1
80.5
total cholesterol measurement
2
3
3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
23
10
99.1
apolipoprotein A 1 measurement
4
97.4
red blood cell density measurement
1
82.3
mean corpuscular volume
1
80.5
total cholesterol measurement
3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 28
VGNC:13695
454183
Macaque
DEAD-box helicase 28
701929
Mouse
MGI:1919236
71986
Rat
RGD:1311976
364995
Dog
DEAD-box helicase 28
VGNC:39853
489747
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 28
Macaque
DEAD-box helicase 28
Mouse
Rat
Dog
DEAD-box helicase 28
Publication Statistics
PubMed Score 6.09
PubMed score by year
PubTator Score 3.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title