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Tbio
DDX24
ATP-dependent RNA helicase DDX24

Protein Summary
Description
ATP-dependent RNA helicase. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330836
  • ENSP00000328690
  • ENSG00000089737
  • ENST00000613280
  • ENSP00000482106
  • ENSG00000273761
  • ENST00000618456
  • ENSP00000478630
  • ENST00000621632
  • ENSP00000481495
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
virus perturbation
0.96
molecular function
0.95
disease perturbation
0.93
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.997752499
p_ni:  0.002247501
Score:  0.258
Data Source:  BioPlex,STRINGDB
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.997061542
p_ni:  0.002938458
Score:  0.254
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.991098226
p_ni:  0.008901774
Score:  0.422
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.988249293
p_ni:  0.011750707
Score:  0.385
Data Source:  BioPlex,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.970121652
p_ni:  0.029878348
Score:  0.274
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.967419689
p_ni:  0.032580311
Score:  0.329
Data Source:  BioPlex,STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.963668598
p_ni:  0.036331397
p_wrong:  4e-9
Score:  0.604
Data Source:  BioPlex,STRINGDB
FGF17
Tbio
Novelty:  0.01432991
p_int:  0.959539614
p_ni:  0.040460386
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.959016838
p_ni:  0.040983162
Score:  0.448
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.951746051
p_ni:  0.048253949
Score:  0.926
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
4
88.5
eosinophil count
3
2
4
88.5
eosinophil percentage of leukocytes
2
2
3
86.1
eosinophil percentage of leukocytes
2
2
3
86.1
sum of eosinophil and basophil counts
1
1
1
72.5
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
88.5
eosinophil count
4
88.5
eosinophil percentage of leukocytes
3
86.1
eosinophil percentage of leukocytes
3
86.1
sum of eosinophil and basophil counts
1
72.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 24
453129
Macaque
DEAD-box helicase 24
700253
Mouse
MGI:1351337
27225
Rat
RGD:727929
373065
Dog
DEAD-box helicase 24
VGNC:39851
480421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 24
Macaque
DEAD-box helicase 24
Mouse
Rat
Dog
DEAD-box helicase 24
Publication Statistics
PubMed Score 6.91
PubMed score by year
PubTator Score 3.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title