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Tbio
DDX20
Probable ATP-dependent RNA helicase DDX20

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369702
  • ENSP00000358716
  • ENSG00000064703
  • ENST00000533164
  • ENSP00000434085

Symbol
  • DP103
  • GEMIN3
  • DP103
  • GEMIN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.88
transcription factor binding site profile
0.87
protein domain
0.85
interacting protein
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.64   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.64   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
GEMIN8
Tbio
Novelty:  0.19515325
p_int:  0.99999239
p_ni:  0.00000761
Score:  0.994
Data Source:  BioPlex,STRINGDB
GEMIN2
Tbio
Novelty:  0.02072868
p_int:  0.999943382
p_ni:  0.000056618
Score:  0.999
Data Source:  BioPlex,STRINGDB
USO1
Tbio
Novelty:  0.02066669
p_int:  0.999919673
p_ni:  0.000080327
Score:  0.196
Data Source:  BioPlex,STRINGDB
GEMIN5
Tbio
Novelty:  0.03683801
p_int:  0.999873533
p_ni:  0.000126467
Score:  0.995
Data Source:  BioPlex,STRINGDB
GEMIN6
Tbio
Novelty:  0.02104816
p_int:  0.999871151
p_ni:  0.000128849
Score:  0.995
Data Source:  BioPlex,STRINGDB
GEMIN4
Tbio
Novelty:  0.03731756
p_int:  0.999789508
p_ni:  0.000210492
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.999618995
p_ni:  0.000381005
Score:  0.685
Data Source:  BioPlex,STRINGDB
LSM11
Tbio
Novelty:  0.10694492
p_int:  0.998913153
p_ni:  0.001004283
p_wrong:  0.000082564
Score:  0.883
Data Source:  BioPlex,STRINGDB
STRAP
Tbio
Family:  Enzyme
Novelty:  0.0336013
p_int:  0.99836469
p_ni:  0.00163531
Score:  0.989
Data Source:  BioPlex,STRINGDB
PHAX
Tbio
Novelty:  0.04027466
p_int:  0.997926893
p_ni:  0.002073107
Score:  0.975
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
84.6
electrocardiography
1
2
52
81.2
waist-hip ratio
2
2
2
70.4
2
1
0
1.1
63.7
body height
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
84.6
electrocardiography
52
81.2
waist-hip ratio
2
70.4
0
1.1
63.7
body height
1
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 20
VGNC:10595
457107
Mouse
MGI:1858415
53975
Rat
RGD:621744
84473
Dog
DEAD-box helicase 20
VGNC:39848
100856065
Horse
DEAD-box helicase 20
VGNC:17085
100063604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 20
Mouse
Rat
Dog
DEAD-box helicase 20
Horse
DEAD-box helicase 20
Publication Statistics
PubMed Score 55.64
PubMed score by year
PubTator Score 35.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title