Tbio DDX19B ATP-dependent RNA helicase DDX19B

Protein Summary

Description

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UMR2
• B3KNE9
• B4DXS6
• E7EMK4
• Q6FIB7
• Q6IAE0
• Q96KE7
• Q9H0U0

Gene Name

• DDX19B

Ensembl ID

• ENST00000288071
• ENSP00000288071
• ENSG00000157349
• ENST00000355992
• ENSP00000348271
• ENST00000393657
• ENSP00000377267
• ENST00000451014
• ENSP00000392639
• ENST00000563392
• ENSP00000456574
• ENST00000568625
• ENSP00000456757

Symbol

• DBP5
• DDX19
• TDBP
• DBP5
• RNAh
• DDX19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
molecular function	0.94
kinase perturbation	0.84
interacting protein	0.82
co-expressed gene	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.25   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 298   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.25   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0