You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
DDX19A
ATP-dependent RNA helicase DDX19A

Protein Summary
Description
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302243
  • ENSP00000306117
  • ENSG00000168872

Symbol
  • DDX19L
  • DDX19L
  • DDX19-DDX19L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
protein complex
0.98
molecular function
0.94
virus perturbation
0.92
kinase perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999999996
p_ni:  4e-9
Score:  0.256
Data Source:  BioPlex,STRINGDB
CTIF
Tbio
Novelty:  0.0764323
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.871
Data Source:  BioPlex,STRINGDB
DDX25
Tbio
Family:  Enzyme
Novelty:  0.04593291
p_int:  0.999998803
p_wrong:  0.000001196
Score:  0.53
Data Source:  BioPlex,STRINGDB
NUP214
Tbio
Novelty:  0.00924336
p_int:  0.994065716
p_ni:  0.005934284
Score:  0.945
Data Source:  BioPlex,STRINGDB
NUP88
Tbio
Novelty:  0.02483503
p_int:  0.983006001
p_ni:  0.016993999
Score:  0.882
Data Source:  BioPlex,STRINGDB
MIF4GD
Tbio
Novelty:  0.04798623
p_int:  0.971350381
p_ni:  1.61e-7
p_wrong:  0.028649458
Score:  0.877
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.881054273
p_ni:  0.118945727
Score:  0.848
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.983
Data Source:  STRINGDB
GLE1
Tbio
Novelty:  0.01655737
Score:  0.92
Data Source:  STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
Score:  0.823
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
isoleucine measurement
2
2
1
9.5
89.8
leucine measurement
1
1
0
10
66.4
valine measurement
1
1
0
9.5
64.3
body height
1
1
1
63.1
amino acid measurement
1
1
1
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
isoleucine measurement
1
9.5
89.8
leucine measurement
0
10
66.4
valine measurement
0
9.5
64.3
body height
1
63.1
amino acid measurement
1
48
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP-dependent RNA helicase DDX19A-like
107966214
Mouse
MGI:99526
13680
Dog
DEAD-box helicase 19A
VGNC:53331
479658
Cow
DEAD-box helicase 19A
VGNC:52191
529929
Xenopus
DEAD-box helicase 19B
XB-GENE-5902964
394732
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP-dependent RNA helicase DDX19A-like
Mouse
Dog
DEAD-box helicase 19A
Cow
DEAD-box helicase 19A
Xenopus
DEAD-box helicase 19B
Publication Statistics
PubMed Score 3.83
PubMed score by year
PubTator Score 19.84
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title