Tdark DDX19A ATP-dependent RNA helicase DDX19A

Protein Summary

Description

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

Uniprot Accession IDs

• Q9NUU7
• B2RPL0
• B4DRZ7
• Q53FM0

Gene Name

• DDX19A

Ensembl ID

• ENST00000302243
• ENSP00000306117
• ENSG00000168872

Symbol

• DDX19L
• DDX19L
• DDX19-DDX19L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
protein complex	0.98
molecular function	0.94
virus perturbation	0.92
kinase perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0