Tbio DDX18 ATP-dependent RNA helicase DDX18

Protein Summary

Description

Probable RNA-dependent helicase. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NVP1
• Q6GTZ9
• Q6IAU4
• Q92732
• Q9BQB7

Gene Name

• DDX18

Ensembl ID

• ENST00000263239
• ENSP00000263239
• ENSG00000088205

Symbol

• cPERP-D
• Has1
• MrDb

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
interacting protein	0.99
molecular function	0.99
co-expressed gene	0.94

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0