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Tbio
DDX18
ATP-dependent RNA helicase DDX18

Protein Summary
Description
Probable RNA-dependent helicase. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263239
  • ENSP00000263239
  • ENSG00000088205

Symbol
  • cPERP-D
  • Has1
  • MrDb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
interacting protein
0.99
molecular function
0.99
co-expressed gene
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (356)
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.95923833
p_ni:  0.04076167
Score:  0.15
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.95174799
p_ni:  0.04825201
Score:  0.363
Data Source:  BioPlex,STRINGDB
RPL7L1
Tdark
Novelty:  0.78428937
p_int:  0.898192925
p_ni:  0.101807075
Score:  0.901
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.879614015
p_ni:  0.120385985
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.873226651
p_ni:  0.126773349
Score:  0.184
Data Source:  BioPlex,STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.873180047
p_ni:  0.126819953
Data Source:  BioPlex
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.854072994
p_ni:  0.145927006
Score:  0.172
Data Source:  BioPlex,STRINGDB
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.847057496
p_ni:  0.152942504
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.831026252
p_ni:  0.168973747
Score:  0.289
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.79639627
p_ni:  0.20360373
Score:  0.498
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
2
2
72.7
vitamin D measurement
3
1
3
60.8
low density lipoprotein cholesterol measurement
1
2
2
60.4
total cholesterol measurement
1
2
2
58.5
apolipoprotein B measurement
1
2
2
55.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
72.7
vitamin D measurement
3
60.8
low density lipoprotein cholesterol measurement
2
60.4
total cholesterol measurement
2
58.5
apolipoprotein B measurement
2
55.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 18
VGNC:10761
459566
Macaque
DEAD-box helicase 18
693278
Mouse
MGI:1914192
66942
Rat
RGD:1549712
308490
Dog
DEAD-box helicase 18
VGNC:39847
476120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 18
Macaque
DEAD-box helicase 18
Mouse
Rat
Dog
DEAD-box helicase 18
Publication Statistics
PubMed Score 29.46
PubMed score by year
PubTator Score 5.46
PubTator score by year
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Related Publications
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PMID
Year
Title