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Tbio
DDX11
ATP-dependent DNA helicase DDX11

Protein Summary
Description
DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228264
  • ENSP00000228264
  • ENSG00000013573
  • ENST00000350437
  • ENSP00000309965
  • ENST00000435753
  • ENSP00000406799
  • ENST00000542838
  • ENSP00000443426
  • ENST00000545668
  • ENSP00000440402

Symbol
  • CHL1
  • CHLR1
  • KRG2
  • CHL1
  • KRG2
  • WABS
  • CHLR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
histone modification site profile
0.91
co-expressed gene
0.89
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.12   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.12   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.999929427
p_ni:  0.000070573
Data Source:  BioPlex
KBTBD4
Tdark
Novelty:  0.35515885
p_int:  0.999764707
p_ni:  0.000235246
p_wrong:  4.7e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.999708736
p_ni:  0.000291264
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.999539465
p_ni:  0.000460534
Data Source:  BioPlex
AVIL
Tbio
Novelty:  0.0175973
p_int:  0.999421261
p_ni:  0.000578739
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.999252171
p_ni:  0.000747824
p_wrong:  5e-9
Data Source:  BioPlex
TENT5A
Tbio
Novelty:  0.08412895
p_int:  0.998985883
p_ni:  0.001014116
p_wrong:  1e-9
Score:  0.299
Data Source:  BioPlex,STRINGDB
IARS2
Tchem
Family:  Enzyme
Novelty:  0.00854621
p_int:  0.995818336
p_ni:  0.004176554
p_wrong:  0.00000511
Score:  0.16
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.995362693
p_ni:  0.004637303
p_wrong:  4e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.994681537
p_ni:  0.003886065
p_wrong:  0.001432398
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443590
320209
Rat
RGD:1306675
316767
Dog
DEAD/H-box helicase 11
486745
Opossum
DEAD/H-box helicase 11
100020572
Platypus
DEAD/H-box helicase 11
100087736
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
DEAD/H-box helicase 11
Opossum
DEAD/H-box helicase 11
Platypus
DEAD/H-box helicase 11
Publication Statistics
PubMed Score 57.12
PubMed score by year
PubTator Score 28.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title