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Tchem
DDX1
ATP-dependent RNA helicase DDX1

Protein Summary
Description
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermedi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233084
  • ENSP00000233084
  • ENSG00000079785
  • ENST00000381341
  • ENSP00000370745

Symbol
  • DBP-RB
  • UKVH5d
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
molecular function
1
disease perturbation
0.97
protein domain
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.74   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.74   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (205)
FAM98C
Tdark
Novelty:  14.23728814
p_int:  1
Score:  0.89
Data Source:  BioPlex,STRINGDB
C2orf49
Tbio
Novelty:  0.03911934
p_int:  0.999999999
p_ni:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
FAM98A
Tdark
Novelty:  0.30067413
p_int:  0.999994152
p_ni:  0.000005849
Score:  0.993
Data Source:  BioPlex,STRINGDB
FGA
Tbio
Novelty:  0.00107227
p_int:  0.999993911
p_ni:  0.000006089
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.999993491
p_ni:  0.000006505
p_wrong:  4e-9
Data Source:  BioPlex
FGG
Tbio
Novelty:  0.00404457
p_int:  0.999986839
p_ni:  0.000013161
Data Source:  BioPlex
FAM98B
Tdark
Novelty:  0.47641513
p_int:  0.999643472
p_ni:  0.000356528
Score:  0.999
Data Source:  BioPlex,STRINGDB
RTCB
Tbio
Family:  Enzyme
Novelty:  0.01114311
p_int:  0.955949187
p_ni:  0.044050813
Score:  0.998
Data Source:  BioPlex,STRINGDB
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.863752642
p_ni:  0.136247358
Score:  0.205
Data Source:  BioPlex,STRINGDB
RTRAF
Tbio
Novelty:  0.03996206
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
3
5
7.8
90.3
urate measurement
2
2
2
73.8
1
2
0
1.4
64.2
self reported educational attainment
1
1
1
24.5
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
7.8
90.3
urate measurement
2
73.8
0
1.4
64.2
self reported educational attainment
1
24.5
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 1
VGNC:48964
459042
Macaque
DEAD-box helicase 1
698327
Mouse
MGI:2144727
104721
Rat
RGD:619903
84474
Dog
DEAD-box helicase 1
VGNC:39844
475671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 1
Macaque
DEAD-box helicase 1
Mouse
Rat
Dog
DEAD-box helicase 1
Publication Statistics
PubMed Score 63.74
PubMed score by year
PubTator Score 45.98
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title