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Tbio
DDT
D-dopachrome decarboxylase

Protein Summary
Description
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350608
  • ENSP00000215773
  • ENSG00000099977
  • ENST00000398344
  • ENSP00000381386
  • ENST00000430101
  • ENSP00000399768
  • ENST00000615721
  • ENSP00000481175
  • ENSG00000275003
  • ENST00000626871
  • ENSP00000486829
  • ENST00000629401
  • ENSP00000486384

Symbol
  • D-DT
  • DDCT
  • MIF2
  • MIF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
tissue sample
0.59
transcription factor perturbation
0.54
cell type or tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.27   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.27   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0