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Tchem
DDOST
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

Protein Summary
Description
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375048
  • ENSP00000364188
  • ENSG00000244038
  • ENST00000415136
  • ENSP00000399457

Symbol
  • KIAA0115
  • OST48
  • OST
  • WBP1
  • AGER1
  • CDG1R
  • GATD6
  • OST48
  • OKSWcl45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.83
kinase perturbation
0.81
co-expressed gene
0.79
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.51   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.51   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
CHEMBL609697
Rendered image for CHEMBL609697
CHEMBL1160689
Rendered image for CHEMBL1160689
CHEMBL609698
Rendered image for CHEMBL609698
CHEMBL609696
Rendered image for CHEMBL609696
CHEMBL1160693
Rendered image for CHEMBL1160693
CHEMBL1160688
Rendered image for CHEMBL1160688
CHEMBL609446
Rendered image for CHEMBL609446
CHEMBL1160687
Rendered image for CHEMBL1160687
Protein-Protein Interactions (306)
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
p_int:  0.99884941
p_ni:  0.001150589
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
STT3B
Tbio
Family:  Enzyme
Novelty:  0.05813174
Score:  0.999
Data Source:  STRINGDB
MAGT1
Tbio
Novelty:  0.02144318
Score:  0.999
Data Source:  STRINGDB
RPN1
Tbio
Family:  Enzyme
Novelty:  0.00880101
Score:  0.999
Data Source:  STRINGDB
DAD1
Tbio
Family:  Enzyme
Novelty:  0.00653242
Score:  0.999
Data Source:  STRINGDB
STT3A
Tbio
Family:  Enzyme
Novelty:  0.01063504
Score:  0.998
Data Source:  STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
Score:  0.997
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.997
Data Source:  STRINGDB
SSR3
Tbio
Novelty:  0.05838475
Score:  0.994
Data Source:  STRINGDB
SEC61A2
Tdark
Novelty:  1.46395791
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (73)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Asparagine N-linked glycosylation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Asparagine N-linked glycosylation
Immune System
Innate Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
84.6
mean corpuscular volume
1
1
1
83.5
alkaline phosphatase measurement
2
2
1
8.4
76.1
apolipoprotein A 1 measurement
1
1
1
71.5
lymphocyte count
2
2
2
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
84.6
mean corpuscular volume
1
83.5
alkaline phosphatase measurement
1
8.4
76.1
apolipoprotein A 1 measurement
1
71.5
lymphocyte count
2
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
VGNC:9990
744092
Macaque
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
706148
Mouse
MGI:1194508
13200
Rat
RGD:1308970
313648
Dog
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
VGNC:39841
404012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
Macaque
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
Mouse
Rat
Dog
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
Publication Statistics
PubMed Score 63.51
PubMed score by year
PubTator Score 257.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title