Protein Summary
Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019]
- ENST00000368923
- ENSP00000357919
- ENSG00000203797
- ENST00000368924
- ENSP00000357920
- DASOX
- DDO-1
- DDO-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.68 | ||
virus perturbation | 0.59 | ||
tissue | 0.54 | ||
histone modification site profile | 0.52 | ||
gene perturbation | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.97 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 212 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.97 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 212 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (94)
Nearest Tclin Targets (2)
Upstream (2)
Pathways (9)
Reactome (5)
KEGG (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glyoxylate metabolism and glycine degradation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Peroxisomal protein import | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glyoxylate metabolism and glycine degradation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Peroxisomal protein import | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (5)
Components (3)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 2 | 4 | 93.8 | |||||
reticulocyte measurement | 3 | 2 | 3 | 92.7 | |||||
reticulocyte count | 7 | 2 | 7 | 92 | |||||
blood metabolite measurement | 2 | 1 | 8 | 81.7 | |||||
platelet count | 2 | 2 | 2 | 79.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 93.8 | |||||
reticulocyte measurement | 3 | 92.7 | |||||
reticulocyte count | 7 | 92 | |||||
blood metabolite measurement | 8 | 81.7 | |||||
platelet count | 2 | 79.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | D-aspartate oxidase | VGNC:2682 | 100608048 | |||||
Mouse | MGI:1925528 | 70503 | ||||||
Rat | RGD:1595123 | 685325 | ||||||
Dog | D-aspartate oxidase | VGNC:39840 | 475026 | |||||
Horse | D-aspartate oxidase | VGNC:17079 | 100072326 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | D-aspartate oxidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | D-aspartate oxidase | |||||
Horse | D-aspartate oxidase | |||||
Publication Statistics
PubMed Score 42.97
PubMed score by year
PubTator Score 27.73
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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