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Tbio
DDI2
Protein DDI1 homolog 2

Protein Summary
Description
Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000480945
  • ENSP00000417748
  • ENSG00000197312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
cell type or tissue
0.68
histone modification site profile
0.68
transcription factor binding site profile
0.67
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.999994493
p_ni:  0.000005507
Data Source:  BioPlex
NRIP3
Tdark
Novelty:  0.35262559
p_int:  0.999981301
p_ni:  0.000018699
Score:  0.345
Data Source:  BioPlex,STRINGDB
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.999493399
p_ni:  0.000506601
Score:  0.151
Data Source:  BioPlex,STRINGDB
ZNF577
Tdark
Family:  TF
Novelty:  0.29636548
p_int:  0.999044338
p_ni:  0.000955662
Data Source:  BioPlex
NR1H3
Tchem
Family:  NR
Novelty:  0.00394862
p_int:  0.998609285
p_ni:  0.001390715
Score:  0.528
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.981000069
p_ni:  0.018999931
Data Source:  BioPlex
RDH5
Tbio
Family:  Enzyme
Novelty:  0.0111079
p_int:  0.954156095
p_ni:  0.045843905
Score:  0.455
Data Source:  BioPlex,STRINGDB
MOGAT2
Tchem
Family:  Enzyme
Novelty:  0.06314447
p_int:  0.94888187
p_ni:  0.05111813
Data Source:  BioPlex
HP1BP3
Tbio
Novelty:  0.07014109
p_int:  0.948427884
p_ni:  0.051572116
Score:  0.189
Data Source:  BioPlex,STRINGDB
RAD23B
Tbio
Novelty:  0.00672104
p_int:  0.924527457
p_ni:  0.075472543
Score:  0.656
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
6
5
8.2
94.3
urate measurement
2
2
2
88.7
creatinine measurement
3
3
3
82.3
chronotype measurement
3
2
2
1
78.2
heel bone mineral density
2
1
2
76.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
8.2
94.3
urate measurement
2
88.7
creatinine measurement
3
82.3
chronotype measurement
2
1
78.2
heel bone mineral density
2
76.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA damage inducible 1 homolog 2
VGNC:11310
739922
Macaque
protein DDI1 homolog 2
695047
Mouse
MGI:1917244
68817
Dog
DNA damage inducible 1 homolog 2
VGNC:52126
487429
Horse
DNA damage inducible 1 homolog 2
VGNC:50682
100054192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA damage inducible 1 homolog 2
Macaque
protein DDI1 homolog 2
Mouse
Dog
DNA damage inducible 1 homolog 2
Horse
DNA damage inducible 1 homolog 2
Publication Statistics
PubMed Score 13.14
PubMed score by year
PubTator Score 3.56
PubTator score by year
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Related Publications
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PMID
Year
Title