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Tbio
DDI1
Protein DDI1 homolog 1

Protein Summary
Description
Probable aspartic protease.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302259
  • ENSP00000302805
  • ENSG00000170967
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
cell line
0.63
cell type or tissue
0.62
tissue sample
0.61
microRNA
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
NRIP3
Tdark
Novelty:  0.35262559
p_int:  0.999971378
p_ni:  0.000028616
p_wrong:  6e-9
Score:  0.455
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.999892659
p_ni:  0.000107341
Score:  0.204
Data Source:  BioPlex,STRINGDB
PHC3
Tbio
Novelty:  0.00091911
p_int:  0.997581054
p_ni:  0.002407066
p_wrong:  0.00001188
Score:  0.534
Data Source:  BioPlex,STRINGDB
SFXN1
Tbio
Novelty:  0.09832047
p_int:  0.997468882
p_ni:  0.002531112
p_wrong:  5e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
PRRT2
Tbio
Novelty:  0.00442931
p_int:  0.995813498
p_ni:  0.004186501
Score:  0.23
Data Source:  BioPlex,STRINGDB
RSC1A1
Tbio
Novelty:  0.23664927
p_int:  0.991252932
p_ni:  0.000004459
p_wrong:  0.008742609
Score:  0.61
Data Source:  BioPlex,STRINGDB
MAPK10
Tchem
Family:  Kinase
Novelty:  0.00420573
p_int:  0.918843494
p_ni:  0.081156506
Score:  0.297
Data Source:  BioPlex,STRINGDB
UBQLN1
Tbio
Novelty:  0.00921991
Score:  0.892
Data Source:  STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
Score:  0.883
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.872
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
60.1
adrenal suppression measurement
2
1
0
5
39.6
response to corticosteroid
2
1
0
5
39.6
apolipoprotein A 1 measurement
1
1
1
30.2
high density lipoprotein cholesterol measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
60.1
adrenal suppression measurement
0
5
39.6
response to corticosteroid
0
5
39.6
apolipoprotein A 1 measurement
1
30.2
high density lipoprotein cholesterol measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919079
71829
Dog
DNA damage inducible 1 homolog 1
VGNC:39834
611726
Horse
DNA damage inducible 1 homolog 1
VGNC:17074
100061526
Cow
DNA damage inducible 1 homolog 1
VGNC:27945
539082
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
DNA damage inducible 1 homolog 1
Horse
DNA damage inducible 1 homolog 1
Cow
DNA damage inducible 1 homolog 1
Publication Statistics
PubMed Score 34.01
PubMed score by year
PubTator Score 8.25
PubTator score by year
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Related Publications
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PMID
Year
Title