Tbio DDHD2 Phospholipase DDHD2

Protein Summary

Description

Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. This gene encodes a phospholipase enzyme containing sterile-alpha-motif (SAM), WWE, and DDHD domains. This protein participates in membrane trafficking between the endoplastic reticulum and the Golgi body. Mutations in this gene can cause autosomal recessive spastic paraplegia 54. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• O94830
• B3KWV2
• B3KXB5
• Q9H8X7

Gene Name

• DDHD2

Ensembl ID

• ENST00000397166
• ENSP00000380352
• ENSG00000085788
• ENST00000517385
• ENSP00000429017
• ENST00000520272
• ENSP00000429932

Symbol

• KIAA0725
• SAMWD1
• SPG54
• SAMWD1
• iPLA(1)gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
histone modification site profile	0.78
microRNA	0.74
protein domain	0.73
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Phospholipase Ddhd2

Protein / Hydrolase / Lipase / Phospholipase / Phospholipase Ddhd2

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Phospholipase Ddhd2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0