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Tbio
DDB2
DNA damage-binding protein 2

Protein Summary
Description
Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256996
  • ENSP00000256996
  • ENSG00000134574
  • ENST00000378600
  • ENSP00000367863
  • ENST00000378601
  • ENSP00000367864
  • ENST00000378603
  • ENSP00000367866
  • ENST00000616278
  • ENSP00000478411

Symbol
  • XPE
  • DDBB
  • UV-DDB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
kinase perturbation
0.84
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.75
interacting protein
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.21   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.21   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (242)
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999999764
p_ni:  2.36e-7
Score:  0.986
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.999991501
p_ni:  0.000008499
Score:  0.984
Data Source:  BioPlex,STRINGDB
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.999990769
p_ni:  0.000009231
Score:  0.98
Data Source:  BioPlex,STRINGDB
CRYBA4
Tbio
Novelty:  0.03692663
p_int:  0.999962454
p_ni:  0.000037546
Score:  0.547
Data Source:  BioPlex,STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999896428
p_ni:  0.000103572
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999850511
p_ni:  0.000149489
Score:  0.988
Data Source:  BioPlex,STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.999747729
p_ni:  0.000252271
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
TIGD3
Tdark
Novelty:  1.23642174
p_int:  0.99969992
p_ni:  0.00030008
Data Source:  BioPlex
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999537824
p_ni:  0.000462176
Data Source:  BioPlex
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.998546336
p_ni:  0.001453576
p_wrong:  8.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (49)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Dual Incision in GG-NER
Reactome
Formation of Incision Complex in GG-NER
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Dual Incision in GG-NER
Formation of Incision Complex in GG-NER
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
17
26
99.6
apolipoprotein A 1 measurement
2
6
7
98.3
triglyceride measurement
4
8
8
96
IGF-1 measurement
1
5
5
95.2
glucose measurement
3
6
6
95.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
26
99.6
apolipoprotein A 1 measurement
7
98.3
triglyceride measurement
8
96
IGF-1 measurement
5
95.2
glucose measurement
6
95.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
damage specific DNA binding protein 2
VGNC:7513
451165
Macaque
damage specific DNA binding protein 2
713813
Mouse
MGI:1355314
107986
Rat
RGD:1310164
100362121
Dog
damage specific DNA binding protein 2
VGNC:39830
483626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
damage specific DNA binding protein 2
Macaque
damage specific DNA binding protein 2
Mouse
Rat
Dog
damage specific DNA binding protein 2
Publication Statistics
PubMed Score 181.21
PubMed score by year
PubTator Score 122.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title