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Tbio
DDB1
DNA damage-binding protein 1

Protein Summary
Description
Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate thei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301764
  • ENSP00000301764
  • ENSG00000167986

Symbol
  • XAP1
  • XPE
  • DDBA
  • XAP1
  • XPCE
  • XPE-BF
  • UV-DDB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.99
hub protein
0.98
protein complex
0.98
co-expressed gene
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.54   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.54   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (352)
TRPC4AP
Tbio
Novelty:  0.02170224
p_int:  0.999045887
p_ni:  0.000954113
Score:  0.949
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.998241473
p_ni:  0.001758527
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
p_int:  0.996081967
p_ni:  0.003918033
Score:  0.987
Data Source:  BioPlex,STRINGDB
DET1
Tbio
Novelty:  0.01138079
p_int:  0.99588061
p_ni:  0.00411939
Score:  0.993
Data Source:  BioPlex,STRINGDB
DCAF11
Tbio
Novelty:  0.08318661
p_int:  0.995521889
p_ni:  0.004478111
Score:  0.984
Data Source:  BioPlex,STRINGDB
DCAF8
Tbio
Novelty:  0.12456534
p_int:  0.992833319
p_ni:  0.007166681
Score:  0.966
Data Source:  BioPlex,STRINGDB
DCAF8L2
Tdark
Novelty:  6.73057868
p_int:  0.97640067
p_ni:  0.02359933
Score:  0.436
Data Source:  BioPlex,STRINGDB
DTL
Tbio
Novelty:  0.01659105
p_int:  0.95015038
p_ni:  0.04984962
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
DCAF4
Tbio
Novelty:  0.24190895
p_int:  0.906072839
p_ni:  0.093927161
Score:  0.967
Data Source:  BioPlex,STRINGDB
CCNG1
Tbio
Novelty:  0.00838635
p_int:  0.889867908
p_ni:  0.110132092
Score:  0.232
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (225)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Damage Recognition in GG-NER
DNA Repair
Dual Incision in GG-NER
Dual incision in TC-NER
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
42.9
fatty acid measurement
1
1
1
37.7
phosphatidylcholine measurement
1
1
1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
42.9
fatty acid measurement
1
37.7
phosphatidylcholine measurement
1
3.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
damage specific DNA binding protein 1
VGNC:7512
451234
Macaque
damage specific DNA binding protein 1
694253
Mouse
MGI:1202384
13194
Rat
RGD:621889
64470
Dog
damage specific DNA binding protein 1
VGNC:39829
476067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
damage specific DNA binding protein 1
Macaque
damage specific DNA binding protein 1
Mouse
Rat
Dog
damage specific DNA binding protein 1
Publication Statistics
PubMed Score 322.54
PubMed score by year
PubTator Score 158.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title