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Tbio
DDAH2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

Protein Summary
Description
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375787
  • ENSP00000364943
  • ENSG00000213722
  • ENST00000375789
  • ENSP00000364945
  • ENST00000375792
  • ENSP00000364949
  • ENST00000383409
  • ENSP00000372901
  • ENSG00000206395
  • ENST00000400062
  • ENSP00000382935
  • ENST00000400063
  • ENSP00000382936
  • ENST00000411456
  • ENSP00000409396
  • ENSG00000226634
  • ENST00000413532
  • ENSP00000402594
  • ENST00000413655
  • ENSP00000412800
  • ENSG00000233076
  • ENST00000414455
  • ENSP00000404342
  • ENSG00000225635
  • ENST00000424790
  • ENSP00000391632
  • ENST00000426149
  • ENSP00000412327
  • ENSG00000228128
  • ENST00000427126
  • ENSP00000395372
  • ENST00000430482
  • ENSP00000408148
  • ENSG00000227317
  • ENST00000434464
  • ENSP00000391833
  • ENST00000437889
  • ENSP00000399023
  • ENST00000443533
  • ENSP00000389552
  • ENST00000444699
  • ENSP00000404851
  • ENST00000447101
  • ENSP00000405515
  • ENST00000451411
  • ENSP00000403154
  • ENST00000454138
  • ENSP00000399357

Symbol
  • DDAH
  • G6A
  • NG30
  • G6a
  • DDAH
  • NG30
  • DDAHII
  • HEL-S-277
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
PubMedID
0.92
transcription factor binding site profile
0.76
phenotype
0.69
transcription factor
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.04   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.04   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
DDAH1
Tchem
Family:  Enzyme
Novelty:  0.00354695
p_int:  0.999999687
p_ni:  3.12e-7
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.999997933
p_ni:  0.000002036
p_wrong:  3.1e-8
Score:  0.559
Data Source:  BioPlex,STRINGDB
EPB41L2
Tbio
Novelty:  0.0311733
p_int:  0.999660381
p_ni:  0.000339619
Score:  0.747
Data Source:  BioPlex,STRINGDB
HYI
Tbio
Family:  Enzyme
Novelty:  0.01805522
p_int:  0.998532575
p_ni:  0.001467409
p_wrong:  1.6e-8
Data Source:  BioPlex
CLNS1A
Tbio
Novelty:  0.01824362
p_int:  0.993311583
p_ni:  0.006688417
Score:  0.625
Data Source:  BioPlex,STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
p_int:  0.972458567
p_ni:  0.027541433
Score:  0.228
Data Source:  BioPlex,STRINGDB
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
p_int:  0.951918029
p_ni:  0.048081971
Score:  0.228
Data Source:  BioPlex,STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
p_int:  0.925203674
p_ni:  0.071263349
p_wrong:  0.003532977
Score:  0.169
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.915766659
p_ni:  0.084233339
p_wrong:  2e-9
Score:  0.705
Data Source:  BioPlex,STRINGDB
SLC25A35
Tdark
Family:  Transporter
Novelty:  1.19834062
p_int:  0.772967785
p_ni:  0.178477632
p_wrong:  0.048554583
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
eNOS activation
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nitric oxide: eNOS activation and regulation
eNOS activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (490)
Items per page:
1 – 5 of 490
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
Items per page:
1 – 5 of 490
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dimethylarginine dimethylaminohydrolase 2
VGNC:11055
745121
Mouse
MGI:1859016
51793
Rat
RGD:1302955
294239
Dog
dimethylarginine dimethylaminohydrolase 2
VGNC:39828
474846
Horse
dimethylarginine dimethylaminohydrolase 2
VGNC:17068
100050594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dimethylarginine dimethylaminohydrolase 2
Mouse
Rat
Dog
dimethylarginine dimethylaminohydrolase 2
Horse
dimethylarginine dimethylaminohydrolase 2
Publication Statistics
PubMed Score 354.04
PubMed score by year
PubTator Score 85.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title