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Tbio
DCXR
L-xylulose reductase

Protein Summary
Description
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306869
  • ENSP00000303356
  • ENSG00000169738

Symbol
  • SDR20C1
  • XR
  • DCR
  • HCR2
  • P34H
  • HCRII
  • KIDCR
  • PNTSU
  • SDR20C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.96
cellular component
0.79
virus perturbation
0.79
histone modification site profile
0.76
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.26   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.26   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
SPHK1
Tchem
Family:  Kinase
Novelty:  0.00147889
p_int:  0.999625391
p_ni:  0.000374609
Score:  0.622
Data Source:  BioPlex,STRINGDB
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.996725396
p_ni:  0.003274604
Score:  0.248
Data Source:  BioPlex,STRINGDB
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.949636818
p_ni:  0.050363182
Score:  0.189
Data Source:  BioPlex,STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
Score:  0.94
Data Source:  STRINGDB
AKR1B10
Tchem
Family:  Enzyme
Novelty:  0.00533958
Score:  0.924
Data Source:  STRINGDB
SORD
Tchem
Family:  Enzyme
Novelty:  0.0040485
Score:  0.918
Data Source:  STRINGDB
RHBDF1
Tbio
Family:  Enzyme
Novelty:  0.01942693
Score:  0.902
Data Source:  STRINGDB
CRYZ
Tbio
Family:  Enzyme
Novelty:  0.00168463
Score:  0.869
Data Source:  STRINGDB
SIM2
Tbio
Novelty:  0.00773416
Score:  0.716
Data Source:  STRINGDB
C11orf54
Tbio
Family:  Enzyme
Novelty:  0.5374767
Score:  0.679
Data Source:  STRINGDB
Pathways (10)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Essential pentosuria
Reactome
Formation of xylulose-5-phosphate
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Essential pentosuria
Formation of xylulose-5-phosphate
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
76.5
vital capacity
1
1
1
73.2
BMI-adjusted waist-hip ratio
2
3
3
58.3
blood metabolite measurement
1
1
1
57.3
birth weight
2
2
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
76.5
vital capacity
1
73.2
BMI-adjusted waist-hip ratio
3
58.3
blood metabolite measurement
1
57.3
birth weight
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dicarbonyl and L-xylulose reductase
VGNC:12087
454983
Macaque
dicarbonyl and L-xylulose reductase
715513
Mouse
MGI:1915130
67880
Rat
RGD:620031
171408
Dog
dicarbonyl and L-xylulose reductase
VGNC:39825
475926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dicarbonyl and L-xylulose reductase
Macaque
dicarbonyl and L-xylulose reductase
Mouse
Rat
Dog
dicarbonyl and L-xylulose reductase
Publication Statistics
PubMed Score 101.26
PubMed score by year
PubTator Score 47.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title