Protein Summary
The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
- ENST00000221114
- ENSP00000221114
- ENSG00000104671
- WS3
- WS3
- p27
- WS-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.96 | ||
histone modification site profile | 0.92 | ||
transcription factor binding site profile | 0.88 | ||
disease perturbation | 0.83 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.49 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 150 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.49 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 150 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
DCTN1
Novelty: 0.00494896
p_int: 0.999999969
p_ni: 3.1e-8
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
DCTN2
Novelty: 0.01045432
p_int: 0.99999926
p_ni: 7.4e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR10
Novelty: 0.11388846
p_int: 0.999999089
p_ni: 9.1e-7
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Novelty: 0.14014918
p_int: 0.999996447
p_ni: 0.000003553
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
DCTN5
Novelty: 0.19530162
p_int: 0.999994706
p_ni: 0.000005292
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ZBTB43
Family: TF
Novelty: 0.35735342
p_int: 0.999970633
p_ni: 0.000029346
p_wrong: 2.2e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
DCTN4
Novelty: 0.10319227
p_int: 0.999969722
p_ni: 0.000030278
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR1A
Novelty: 0.06306209
p_int: 0.999941174
p_ni: 0.000058826
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KLHL2
Novelty: 0.07279226
p_int: 0.999843615
p_ni: 0.000156385
Score: 0.377
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (17)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-independent Golgi-to-ER retrograde traffic | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Asparagine N-linked glycosylation | ||||
COPI-independent Golgi-to-ER retrograde traffic | ||||
COPI-mediated anterograde transport | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dynactin subunit 6 | VGNC:894 | 472730 | |||||
Macaque | dynactin subunit 6 | 694273 | ||||||
Mouse | MGI:1343154 | 22428 | ||||||
Rat | RGD:1307549 | 290798 | ||||||
Dog | dynactin subunit 6 | VGNC:39821 | 475600 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dynactin subunit 6 | |||||
Macaque | dynactin subunit 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dynactin subunit 6 | |||||
Publication Statistics
PubMed Score 3.49
PubMed score by year
PubTator Score 362.97
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
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