Tdark DCTN6 Dynactin subunit 6

Protein Summary

Description

The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00399
• B2RAC1

Gene Name

• DCTN6

Ensembl ID

• ENST00000221114
• ENSP00000221114
• ENSG00000104671

Symbol

• WS3
• WS3
• p27
• WS-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
histone modification site profile	0.92
transcription factor binding site profile	0.88
disease perturbation	0.83
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Dynactin Subunit 6

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Dynactin Subunit 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (221)

Explore Interacting Targets

1 – 10 of 221

• See Interactions on String-DB

ACTR1B

Tbio

Novelty:  0.10014723

p_int:  1

Score:  0.997

Data Source:  BioPlex,STRINGDB

DCTN1

Tbio

Novelty:  0.00494896

p_int:  0.999999969

p_ni:  3.1e-8

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

DCTN2

Tbio

Novelty:  0.01045432

p_int:  0.99999926

p_ni:  7.4e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ACTR10

Tbio

Novelty:  0.11388846

p_int:  0.999999089

p_ni:  9.1e-7

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

CAPZA2

Tbio

Novelty:  0.14014918

p_int:  0.999996447

p_ni:  0.000003553

Score:  0.973

Data Source:  BioPlex,Reactome,STRINGDB

DCTN5

Tbio

Novelty:  0.19530162

p_int:  0.999994706

p_ni:  0.000005292

p_wrong:  2e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

ZBTB43

Tdark

Family:  TF

Novelty:  0.35735342

p_int:  0.999970633

p_ni:  0.000029346

p_wrong:  2.2e-8

Score:  0.158

Data Source:  BioPlex,STRINGDB

DCTN4

Tbio

Novelty:  0.10319227

p_int:  0.999969722

p_ni:  0.000030278

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ACTR1A

Tbio

Novelty:  0.06306209

p_int:  0.999941174

p_ni:  0.000058826

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

KLHL2

Tbio

Novelty:  0.07279226

p_int:  0.999843615

p_ni:  0.000156385

Score:  0.377

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (17)

KEGG (1)

Adaptive Immune System (R-HSA-1280218)

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5

1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436
Reactome	COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436
COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (4)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
centrosome	Inferred from Direct Assay (IDA)	UniProtKB
cytosol	Traceable Author Statement (TAS)	Reactome
condensed chromosome kinetochore	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
dynactin complex	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Centromere
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Kinetochore
Phosphoprotein
Reference proteome

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dynactin subunit 6	VGNC:894	472730
Macaque	dynactin subunit 6		694273
Mouse	dynactin 6	MGI:1343154	22428
Rat	dynactin subunit 6	RGD:1307549	290798
Dog	dynactin subunit 6	VGNC:39821	475600

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dynactin subunit 6
Macaque	dynactin subunit 6
Mouse	dynactin 6
Rat	dynactin subunit 6
Dog	dynactin subunit 6

Publication Statistics

PubMed Score 3.49

PubMed score by year

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PubTator Score 362.97

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title