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Tdark
DCTN6
Dynactin subunit 6

Protein Summary
Description
The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221114
  • ENSP00000221114
  • ENSG00000104671

Symbol
  • WS3
  • WS3
  • p27
  • WS-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.92
transcription factor binding site profile
0.88
disease perturbation
0.83
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (221)
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  1
Score:  0.997
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.999999969
p_ni:  3.1e-8
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
p_int:  0.99999926
p_ni:  7.4e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.999999089
p_ni:  9.1e-7
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999996447
p_ni:  0.000003553
Score:  0.973
Data Source:  BioPlex,Reactome,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.999994706
p_ni:  0.000005292
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ZBTB43
Tdark
Family:  TF
Novelty:  0.35735342
p_int:  0.999970633
p_ni:  0.000029346
p_wrong:  2.2e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.999969722
p_ni:  0.000030278
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACTR1A
Tbio
Novelty:  0.06306209
p_int:  0.999941174
p_ni:  0.000058826
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999843615
p_ni:  0.000156385
Score:  0.377
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 6
VGNC:894
472730
Macaque
dynactin subunit 6
694273
Mouse
MGI:1343154
22428
Rat
RGD:1307549
290798
Dog
dynactin subunit 6
VGNC:39821
475600
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 6
Macaque
dynactin subunit 6
Mouse
Rat
Dog
dynactin subunit 6
Publication Statistics
PubMed Score 3.49
PubMed score by year
PubTator Score 362.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title