Protein Summary
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
- ENST00000300087
- ENSP00000300087
- ENSG00000166847
- ENST00000563998
- ENSP00000454691
- ENST00000568272
- ENSP00000455685
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.91 | ||
microRNA | 0.9 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.82 | ||
cell type or tissue | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.01 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 83 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.01 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 83 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (225)
ACTR10
Novelty: 0.11388846
p_int: 0.999999165
p_ni: 8.35e-7
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Novelty: 0.30624393
p_int: 0.999994706
p_ni: 0.000005292
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
DCTN4
Novelty: 0.10319227
p_int: 0.999993891
p_ni: 0.000006109
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCTN3
Novelty: 0.14551388
p_int: 0.999947901
p_ni: 0.000052099
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
ACTR1B
Novelty: 0.10014723
p_int: 0.999943045
p_ni: 0.000056926
p_wrong: 2.9e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
DCTN1
Novelty: 0.00494896
p_int: 0.999922827
p_ni: 0.000077162
p_wrong: 1.1e-8
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
PDGFD
Novelty: 0.00799996
p_int: 0.999833151
p_ni: 0.000165805
p_wrong: 0.000001044
Score: 0.696
Data Source: BioPlex,STRINGDB
KLHL2
Novelty: 0.07279226
p_int: 0.999696275
p_ni: 0.000303638
p_wrong: 8.7e-8
Score: 0.377
Data Source: BioPlex,STRINGDB
DCTN2
Novelty: 0.01045432
p_int: 0.999413
p_ni: 0.000587
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Novelty: 0.14014918
p_int: 0.99881607
p_ni: 0.001183919
p_wrong: 1.2e-8
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (17)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-independent Golgi-to-ER retrograde traffic | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Asparagine N-linked glycosylation | ||||
COPI-independent Golgi-to-ER retrograde traffic | ||||
COPI-mediated anterograde transport | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
Mycobacterium avium complex disease | 1 | 1 | 1 | 58.4 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
Mycobacterium avium complex disease | 1 | 58.4 | |||||
mean reticulocyte volume | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | dynactin subunit 5 | 698277 | ||||||
Mouse | MGI:1891689 | 59288 | ||||||
Rat | RGD:1305654 | 308961 | ||||||
Dog | dynactin subunit 5 | VGNC:39820 | 479804 | |||||
Horse | dynactin subunit 5 | VGNC:17059 | 100068373 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | dynactin subunit 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dynactin subunit 5 | |||||
Horse | dynactin subunit 5 | |||||
Publication Statistics
PubMed Score 5.01
PubMed score by year
PubTator Score 3.34
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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