Tbio DCTN5 Dynactin subunit 5

Protein Summary

Description

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9BTE1
• A8K9X8
• H3BN51
• H3BQA4

Gene Name

• DCTN5

Ensembl ID

• ENST00000300087
• ENSP00000300087
• ENSG00000166847
• ENST00000563998
• ENSP00000454691
• ENST00000568272
• ENSP00000455685

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
microRNA	0.9
disease perturbation	0.87
transcription factor binding site profile	0.82
cell type or tissue	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.35   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.35   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0