Tbio DCTN5 Dynactin subunit 5

Protein Summary

Description

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9BTE1
• A8K9X8
• H3BN51
• H3BQA4

Gene Name

• DCTN5

Ensembl ID

• ENST00000300087
• ENSP00000300087
• ENSG00000166847
• ENST00000563998
• ENSP00000454691
• ENST00000568272
• ENSP00000455685

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
microRNA	0.9
disease perturbation	0.87
transcription factor binding site profile	0.82
cell type or tissue	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (225)

Explore Interacting Targets

1 – 10 of 225

• See Interactions on String-DB

ACTR10

Tbio

Novelty:  0.11388846

p_int:  0.999999165

p_ni:  8.35e-7

Score:  0.985

Data Source:  BioPlex,Reactome,STRINGDB

DCTN6

Tdark

Novelty:  0.30624393

p_int:  0.999994706

p_ni:  0.000005292

p_wrong:  2e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

DCTN4

Tbio

Novelty:  0.10319227

p_int:  0.999993891

p_ni:  0.000006109

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

DCTN3

Tbio

Novelty:  0.14551388

p_int:  0.999947901

p_ni:  0.000052099

Score:  0.946

Data Source:  BioPlex,Reactome,STRINGDB

ACTR1B

Tbio

Novelty:  0.10014723

p_int:  0.999943045

p_ni:  0.000056926

p_wrong:  2.9e-8

Score:  0.997

Data Source:  BioPlex,STRINGDB

DCTN1

Tbio

Novelty:  0.00494896

p_int:  0.999922827

p_ni:  0.000077162

p_wrong:  1.1e-8

Score:  0.99

Data Source:  BioPlex,Reactome,STRINGDB

PDGFD

Tbio

Novelty:  0.00799996

p_int:  0.999833151

p_ni:  0.000165805

p_wrong:  0.000001044

Score:  0.696

Data Source:  BioPlex,STRINGDB

KLHL2

Tbio

Novelty:  0.07279226

p_int:  0.999696275

p_ni:  0.000303638

p_wrong:  8.7e-8

Score:  0.377

Data Source:  BioPlex,STRINGDB

DCTN2

Tbio

Novelty:  0.01045432

p_int:  0.999413

p_ni:  0.000587

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

CAPZA2

Tbio

Novelty:  0.14014918

p_int:  0.99881607

p_ni:  0.001183919

p_wrong:  1.2e-8

Score:  0.978

Data Source:  BioPlex,Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (17)

KEGG (1)

Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets

Items per page:

5

1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436
Reactome	COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436
COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Components (5)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
centrosome	Inferred from Direct Assay (IDA)	UniProtKB
nuclear membrane	Inferred from Direct Assay (IDA)	HPA
nucleoplasm	Inferred from Direct Assay (IDA)	HPA
cytosol	Traceable Author Statement (TAS)	Reactome
condensed chromosome kinetochore	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Mycobacterium avium complex disease	EFO_0007386	1	1	1		58.4
mean reticulocyte volume	EFO_0010701	1	1	1		44.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Mycobacterium avium complex disease	EFO_0007386	1		58.4
mean reticulocyte volume	EFO_0010701	1		44.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Centromere
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Kinetochore
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
mean reticulocyte volume
Mycobacterium avium complex disease

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
craniofacial phenotype
growth/size/body region phenotype
hematopoietic system phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype
skeleton phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	dynactin subunit 5		698277
Mouse	dynactin 5	MGI:1891689	59288
Rat	dynactin subunit 5	RGD:1305654	308961
Dog	dynactin subunit 5	VGNC:39820	479804
Horse	dynactin subunit 5	VGNC:17059	100068373

Species	Name	OMA	EggNOG	Inparanoid
Macaque	dynactin subunit 5
Mouse	dynactin 5
Rat	dynactin subunit 5
Dog	dynactin subunit 5
Horse	dynactin subunit 5

Publication Statistics

PubMed Score 5.01

PubMed score by year

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PubTator Score 3.34

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title