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Tbio
DCTN5
Dynactin subunit 5

Protein Summary
Description
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300087
  • ENSP00000300087
  • ENSG00000166847
  • ENST00000563998
  • ENSP00000454691
  • ENST00000568272
  • ENSP00000455685
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
microRNA
0.9
disease perturbation
0.87
transcription factor binding site profile
0.82
cell type or tissue
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (225)
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.999999165
p_ni:  8.35e-7
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999994706
p_ni:  0.000005292
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.999993891
p_ni:  0.000006109
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.999947901
p_ni:  0.000052099
Score:  0.946
Data Source:  BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.999943045
p_ni:  0.000056926
p_wrong:  2.9e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.999922827
p_ni:  0.000077162
p_wrong:  1.1e-8
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
PDGFD
Tbio
Novelty:  0.00799996
p_int:  0.999833151
p_ni:  0.000165805
p_wrong:  0.000001044
Score:  0.696
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999696275
p_ni:  0.000303638
p_wrong:  8.7e-8
Score:  0.377
Data Source:  BioPlex,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
p_int:  0.999413
p_ni:  0.000587
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.99881607
p_ni:  0.001183919
p_wrong:  1.2e-8
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Mycobacterium avium complex disease
1
1
1
58.4
mean reticulocyte volume
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Mycobacterium avium complex disease
1
58.4
mean reticulocyte volume
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dynactin subunit 5
698277
Mouse
MGI:1891689
59288
Rat
RGD:1305654
308961
Dog
dynactin subunit 5
VGNC:39820
479804
Horse
dynactin subunit 5
VGNC:17059
100068373
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dynactin subunit 5
Mouse
Rat
Dog
dynactin subunit 5
Horse
dynactin subunit 5
Publication Statistics
PubMed Score 5.01
PubMed score by year
PubTator Score 3.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title