Protein Summary
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
- ENST00000424236
- ENSP00000411251
- ENSG00000132912
- ENST00000446090
- ENSP00000414906
- ENST00000447998
- ENSP00000416968
- P62
- DYN4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.85 | ||
histone modification site profile | 0.8 | ||
kinase perturbation | 0.76 | ||
transcription factor perturbation | 0.74 | ||
cellular component | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.28 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 206 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.28 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 206 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0