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Tbio
DCTN4
Dynactin subunit 4

Protein Summary
Description
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424236
  • ENSP00000411251
  • ENSG00000132912
  • ENST00000446090
  • ENSP00000414906
  • ENST00000447998
  • ENSP00000416968

Symbol
  • P62
  • DYN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
histone modification site profile
0.8
kinase perturbation
0.76
transcription factor perturbation
0.74
cellular component
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (222)
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.999993891
p_ni:  0.000006109
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999969722
p_ni:  0.000030278
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.999950055
p_ni:  0.000049945
Score:  0.996
Data Source:  BioPlex,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
p_int:  0.999948238
p_ni:  0.000051762
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.999889872
p_ni:  0.000110128
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999713444
p_ni:  0.000286556
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999241327
p_ni:  0.000758673
Score:  0.405
Data Source:  BioPlex,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.998277052
p_ni:  0.001722948
Score:  0.696
Data Source:  BioPlex,STRINGDB
ACTR1A
Tbio
Novelty:  0.06306209
p_int:  0.996611013
p_ni:  0.003388987
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
p_int:  0.991836052
p_ni:  0.008163948
Score:  0.69
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
52.4
2
2
1
1.4
47.5
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
52.4
1
1.4
47.5
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 4
VGNC:3965
462195
Macaque
dynactin subunit 4
712783
Mouse
MGI:1914915
67665
Rat
RGD:71023
84428
Dog
dynactin subunit 4
VGNC:39819
479326
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 4
Macaque
dynactin subunit 4
Mouse
Rat
Dog
dynactin subunit 4
Publication Statistics
PubMed Score 10.06
PubMed score by year
PubTator Score 14.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title