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Tbio
DCTN3
Dynactin subunit 3

Protein Summary
Description
Together with dynein may be involved in spindle assembly and cytokinesis. This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259632
  • ENSP00000259632
  • ENSG00000137100
  • ENST00000341694
  • ENSP00000343986
  • ENST00000378916
  • ENSP00000368196

Symbol
  • DCTN22
  • DCTN22
  • DCTN-22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
virus perturbation
0.83
cellular component
0.79
interacting protein
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (313)
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.999947901
p_ni:  0.000052099
Score:  0.946
Data Source:  BioPlex,Reactome,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
p_int:  0.999916035
p_ni:  0.000083965
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.99986763
p_ni:  0.00013237
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999521148
p_ni:  0.000478743
p_wrong:  1.09e-7
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.998435351
p_ni:  0.001564648
p_wrong:  1e-9
Score:  0.951
Data Source:  BioPlex,Reactome,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.997683624
p_ni:  0.002316376
Score:  0.699
Data Source:  BioPlex,STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
p_int:  0.994601085
p_ni:  0.005398915
Score:  0.817
Data Source:  BioPlex,STRINGDB
ACTR1A
Tbio
Novelty:  0.06306209
p_int:  0.99429513
p_ni:  0.00570487
Score:  0.946
Data Source:  BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.993809453
p_ni:  0.006190547
Score:  0.996
Data Source:  BioPlex,STRINGDB
N4BP2L1
Tdark
Novelty:  0.59201222
p_int:  0.989863699
p_ni:  0.010136301
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
2
1.1
88.3
blood protein measurement
4
4
5
84.9
interleukin-11 receptor subunit alpha measurement
1
1
1
74.6
chemokine (C-C motif) ligand 27 measurement
1
1
1
70.9
adolescent idiopathic scoliosis
2
1
0
1.1
64.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
88.3
blood protein measurement
5
84.9
interleukin-11 receptor subunit alpha measurement
1
74.6
chemokine (C-C motif) ligand 27 measurement
1
70.9
adolescent idiopathic scoliosis
0
1.1
64.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 3
VGNC:4706
465061
Macaque
dynactin subunit 3
700703
Mouse
MGI:1859251
53598
Rat
RGD:1309547
362504
Dog
dynactin subunit 3
VGNC:39818
474750
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 3
Macaque
dynactin subunit 3
Mouse
Rat
Dog
dynactin subunit 3
Publication Statistics
PubMed Score 7.73
PubMed score by year
PubTator Score 3.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title