Protein Summary
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced tran ...more
- ENST00000434715
- ENSP00000408910
- ENSG00000175203
- ENST00000543672
- ENSP00000439376
- ENST00000548249
- ENSP00000447824
- DCTN50
- RBP50
- DCTN50
- HEL-S-77
- DYNAMITIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.96 | ||
co-expressed gene | 0.85 | ||
cellular component | 0.79 | ||
transcription factor binding site profile | 0.74 | ||
hub protein | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.23 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 331 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.23 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 331 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (397)
ACTR1B
Novelty: 0.10014723
p_int: 0.999999993
p_ni: 7e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
DCTN1
Novelty: 0.00494896
p_int: 0.999999934
p_ni: 6.6e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Novelty: 0.30624393
p_int: 0.99999926
p_ni: 7.4e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR10
Novelty: 0.11388846
p_int: 0.999998333
p_ni: 0.000001666
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
KLHL2
Novelty: 0.07279226
p_int: 0.99999785
p_ni: 0.00000215
Score: 0.53
Data Source: BioPlex,STRINGDB
BORCS6
Novelty: 0.83789033
p_int: 0.999976323
p_ni: 0.000023675
p_wrong: 2e-9
Data Source: BioPlex
CCDC138
Novelty: 4.02014418
p_int: 0.999953993
p_ni: 0.000010544
p_wrong: 0.000035463
Score: 0.211
Data Source: BioPlex,STRINGDB
DCTN4
Novelty: 0.10319227
p_int: 0.999948238
p_ni: 0.000051762
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
DCTN3
Novelty: 0.14551388
p_int: 0.999916035
p_ni: 0.000083965
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
DCTN5
Novelty: 0.19530162
p_int: 0.999413
p_ni: 0.000587
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (35)
Reactome (33)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-independent Golgi-to-ER retrograde traffic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Adaptive Immune System | ||||
Anchoring of the basal body to the plasma membrane | ||||
Asparagine N-linked glycosylation | ||||
COPI-independent Golgi-to-ER retrograde traffic | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (4)
Components (11)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
urate measurement | 5 | 5 | 8 | 98.6 | |||||
high density lipoprotein cholesterol measurement | 4 | 6 | 10 | 97.1 | |||||
apolipoprotein A 1 measurement | 2 | 3 | 3 | 91.8 | |||||
triglyceride measurement | 3 | 4 | 8 | 88.7 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 10.3 | 76.7 | ||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
urate measurement | 8 | 98.6 | |||||
high density lipoprotein cholesterol measurement | 10 | 97.1 | |||||
apolipoprotein A 1 measurement | 3 | 91.8 | |||||
triglyceride measurement | 8 | 88.7 | |||||
aspartate aminotransferase measurement | 0 | 10.3 | 76.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dynactin subunit 2 | VGNC:5354 | 100615725 | |||||
Macaque | dynactin subunit 2 | 714948 | ||||||
Mouse | MGI:107733 | 69654 | ||||||
Rat | RGD:1303182 | 299850 | ||||||
Dog | dynactin subunit 2 | VGNC:39817 | 474415 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dynactin subunit 2 | |||||
Macaque | dynactin subunit 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dynactin subunit 2 | |||||
Publication Statistics
PubMed Score 82.23
PubMed score by year
PubTator Score 53.08
PubTator score by year
Related Publications
Text Mined References (55)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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