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Tbio
DCTN2
Dynactin subunit 2

Protein Summary
Description
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434715
  • ENSP00000408910
  • ENSG00000175203
  • ENST00000543672
  • ENSP00000439376
  • ENST00000548249
  • ENSP00000447824

Symbol
  • DCTN50
  • RBP50
  • DCTN50
  • HEL-S-77
  • DYNAMITIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
co-expressed gene
0.85
cellular component
0.79
transcription factor binding site profile
0.74
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.23   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.23   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (397)
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.999999993
p_ni:  7e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.999999934
p_ni:  6.6e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.99999926
p_ni:  7.4e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.999998333
p_ni:  0.000001666
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.99999785
p_ni:  0.00000215
Score:  0.53
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999976323
p_ni:  0.000023675
p_wrong:  2e-9
Data Source:  BioPlex
CCDC138
Tdark
Novelty:  4.02014418
p_int:  0.999953993
p_ni:  0.000010544
p_wrong:  0.000035463
Score:  0.211
Data Source:  BioPlex,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.999948238
p_ni:  0.000051762
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.999916035
p_ni:  0.000083965
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.999413
p_ni:  0.000587
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
5
8
98.6
high density lipoprotein cholesterol measurement
4
6
10
97.1
apolipoprotein A 1 measurement
2
3
3
91.8
triglyceride measurement
3
4
8
88.7
aspartate aminotransferase measurement
1
1
0
10.3
76.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
8
98.6
high density lipoprotein cholesterol measurement
10
97.1
apolipoprotein A 1 measurement
3
91.8
triglyceride measurement
8
88.7
aspartate aminotransferase measurement
0
10.3
76.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 2
VGNC:5354
100615725
Macaque
dynactin subunit 2
714948
Mouse
MGI:107733
69654
Rat
RGD:1303182
299850
Dog
dynactin subunit 2
VGNC:39817
474415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 2
Macaque
dynactin subunit 2
Mouse
Rat
Dog
dynactin subunit 2
Publication Statistics
PubMed Score 82.23
PubMed score by year
PubTator Score 53.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title