Tbio DCTN2 Dynactin subunit 2

Protein Summary

Description

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q13561
• B2RBK5
• Q86YN2
• Q9BW17

Gene Name

• DCTN2

Ensembl ID

• ENST00000434715
• ENSP00000408910
• ENSG00000175203
• ENST00000543672
• ENSP00000439376
• ENST00000548249
• ENSP00000447824

Symbol

• DCTN50
• RBP50
• DCTN50
• HEL-S-77
• DYNAMITIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
co-expressed gene	0.85
cellular component	0.79
transcription factor binding site profile	0.74
hub protein	0.71

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Dynactin Subunit 2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Dynactin Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.23   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 331   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.23   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (397)

Explore Interacting Targets

1 – 10 of 397

• See Interactions on String-DB

ACTR1B

Tbio

Novelty:  0.10014723

p_int:  0.999999993

p_ni:  7e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

DCTN1

Tbio

Novelty:  0.00494896

p_int:  0.999999934

p_ni:  6.6e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

DCTN6

Tdark

Novelty:  0.30624393

p_int:  0.99999926

p_ni:  7.4e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ACTR10

Tbio

Novelty:  0.11388846

p_int:  0.999998333

p_ni:  0.000001666

p_wrong:  2e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

KLHL2

Tbio

Novelty:  0.07279226

p_int:  0.99999785

p_ni:  0.00000215

Score:  0.53

Data Source:  BioPlex,STRINGDB

BORCS6

Tdark

Novelty:  0.83789033

p_int:  0.999976323

p_ni:  0.000023675

p_wrong:  2e-9

Data Source:  BioPlex

CCDC138

Tdark

Novelty:  4.02014418

p_int:  0.999953993

p_ni:  0.000010544

p_wrong:  0.000035463

Score:  0.211

Data Source:  BioPlex,STRINGDB

DCTN4

Tbio

Novelty:  0.10319227

p_int:  0.999948238

p_ni:  0.000051762

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

DCTN3

Tbio

Novelty:  0.14551388

p_int:  0.999916035

p_ni:  0.000083965

Score:  0.995

Data Source:  BioPlex,Reactome,STRINGDB

DCTN5

Tbio

Novelty:  0.19530162

p_int:  0.999413

p_ni:  0.000587

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (35)

Reactome (33)

KEGG (2)

AURKA Activation by TPX2 (R-HSA-8854518)

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5

1 – 5 of 33

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Adaptive Immune System	894 targets	R-HSA-1280218
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (25)

Functions (4)

Components (11)

Processes (10)

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Items per page:

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1 – 4 of 4

GO Term	Evidence	Assigned by
spectrin binding	Inferred from Direct Assay (IDA)	MGI
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein kinase binding	Inferred from Physical Interaction (IPI)	ARUK-UCL
motor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	5	5	8		98.6
high density lipoprotein cholesterol measurement	EFO_0004612	4	6	10		97.1
apolipoprotein A 1 measurement	EFO_0004614	2	3	3		91.8
triglyceride measurement	EFO_0004530	3	4	8		88.7
aspartate aminotransferase measurement	EFO_0004736	1	1	0	10.3	76.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	8		98.6
high density lipoprotein cholesterol measurement	EFO_0004612	10		97.1
apolipoprotein A 1 measurement	EFO_0004614	3		91.8
triglyceride measurement	EFO_0004530	8		88.7
aspartate aminotransferase measurement	EFO_0004736	0	10.3	76.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Dynein
Membrane
Microtubule

GWAS Trait Find Similar Targets

No Header	No Header
amyotrophic lateral sclerosis
apolipoprotein A 1 measurement
aspartate aminotransferase measurement
high density lipoprotein cholesterol measurement
IGF-1 measurement
lymphocyte count
monocyte count
monocyte percentage of leukocytes
platelet count
platelet crit

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dynactin subunit 2	VGNC:5354	100615725
Macaque	dynactin subunit 2		714948
Mouse	dynactin 2	MGI:107733	69654
Rat	dynactin subunit 2	RGD:1303182	299850
Dog	dynactin subunit 2	VGNC:39817	474415

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dynactin subunit 2
Macaque	dynactin subunit 2
Mouse	dynactin 2
Rat	dynactin subunit 2
Dog	dynactin subunit 2

Publication Statistics

PubMed Score 82.23

PubMed score by year

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PubTator Score 53.08

PubTator score by year

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Related Publications

Text Mined References (55)

GeneRif Annotations (10)

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PMID	Year	Title