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Tbio
DCTN1
Dynactin subunit 1

Protein Summary
Description
Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361874
  • ENSP00000354791
  • ENSG00000204843
  • ENST00000394003
  • ENSP00000377571
  • ENST00000409240
  • ENSP00000386406
  • ENST00000409438
  • ENSP00000387270
  • ENST00000409567
  • ENSP00000386843
  • ENST00000633691
  • ENSP00000487724

Symbol
  • P135
  • DP-150
  • DAP-150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.91
transcription factor perturbation
0.84
biological process
0.82
transcription factor
0.81
hub protein
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.71   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.71   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0