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Tdark
DCP1B
mRNA-decapping enzyme 1B

Protein Summary
Description
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280665
  • ENSP00000280665
  • ENSG00000151065
  • ENST00000647122
  • ENSP00000494635
  • ENSG00000284850

Symbol
  • DCP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
histone modification site profile
0.68
cell line
0.66
transcription factor
0.66
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
p_int:  0.999999853
p_ni:  1.47e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.999999206
p_ni:  7.94e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
PNLIPRP2
Tbio
Family:  Enzyme
p_int:  0.999998101
p_ni:  0.000001899
Data Source:  BioPlex
EDC3
Tbio
Novelty:  0.02077346
p_int:  0.999996974
p_ni:  0.000003026
Score:  0.998
Data Source:  BioPlex,STRINGDB
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.999986557
p_ni:  0.000013443
Score:  0.776
Data Source:  BioPlex,STRINGDB
PIM1
Tchem
Family:  Kinase
Novelty:  0.0049837
p_int:  0.999978026
p_ni:  0.000021974
Score:  0.875
Data Source:  BioPlex,STRINGDB
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.999887732
p_ni:  0.000112268
Score:  0.156
Data Source:  BioPlex,STRINGDB
SH3BGR
Tbio
Novelty:  0.19912265
p_int:  0.999846086
p_ni:  0.000153914
Score:  0.221
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999741429
p_ni:  0.000258571
Data Source:  BioPlex
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999109267
p_ni:  0.000890733
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 5' to 3' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 5' to 3' exoribonuclease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
57.8
self reported educational attainment
1
1
1
57.8
electrocardiography
1
1
17
49.5
electrocardiography
1
1
17
49.5
visceral adipose tissue measurement
1
1
1
44.2
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
57.8
self reported educational attainment
1
57.8
electrocardiography
17
49.5
electrocardiography
17
49.5
visceral adipose tissue measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
decapping mRNA 1B
VGNC:8398
451743
Macaque
decapping mRNA 1B
708089
Mouse
MGI:2442404
319618
Rat
RGD:1562214
500305
Dog
decapping mRNA 1B
VGNC:39809
477734
Species
Name
OMA
EggNOG
Inparanoid
Chimp
decapping mRNA 1B
Macaque
decapping mRNA 1B
Mouse
Rat
Dog
decapping mRNA 1B
Publication Statistics
PubMed Score 2.90
PubMed score by year
PubTator Score 28.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title