Protein Summary
May affect the rate of fibrils formation. This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
- ENST00000052754
- ENSP00000052754
- ENSG00000011465
- ENST00000393155
- ENSP00000376862
- ENST00000420120
- ENSP00000413723
- ENST00000425043
- ENSP00000401021
- ENST00000441303
- ENSP00000399815
- ENST00000456569
- ENSP00000398514
- ENST00000547568
- ENSP00000447674
- ENST00000552962
- ENSP00000447654
- SLRR1B
- CSCD
- PG40
- PGII
- PGS2
- DSPG2
- SLRR1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 0.95 | ||
PubMedID | 0.94 | ||
disease perturbation | 0.93 | ||
small molecule perturbation | 0.92 | ||
kinase perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1551.3 (req: < 5)
Gene RIFs: 188 (req: <= 3)
Antibodies: 582 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1551.3 (req: >= 5)
Gene RIFs: 188 (req: > 3)
Antibodies: 582 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0