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Tbio
DCLRE1B
5' exonuclease Apollo

Protein Summary
Description
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369563
  • ENSP00000358576
  • ENSG00000118655
  • ENST00000650450
  • ENSP00000498042

Symbol
  • SNM1B
  • SNM1B
  • SNMIB
  • APOLLO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
histone modification site profile
0.84
microRNA
0.67
virus perturbation
0.64
tissue
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.49   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.49   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
p_int:  0.999939665
p_ni:  0.000060335
Score:  0.903
Data Source:  BioPlex,STRINGDB
TINF2
Tbio
Novelty:  0.0064505
Score:  0.989
Data Source:  STRINGDB
TERF1
Tbio
Family:  TF
Novelty:  0.00174529
Score:  0.988
Data Source:  STRINGDB
POT1
Tbio
Novelty:  0.01042607
Score:  0.987
Data Source:  STRINGDB
MUS81
Tbio
Family:  Enzyme
Novelty:  0.00532122
Score:  0.985
Data Source:  STRINGDB
SLX4
Tbio
Family:  Enzyme
Novelty:  0.01677273
Score:  0.983
Data Source:  STRINGDB
EME1
Tbio
Family:  Enzyme
Novelty:  0.017415
Score:  0.98
Data Source:  STRINGDB
FANCD2
Tbio
Novelty:  0.00316101
Score:  0.975
Data Source:  STRINGDB
ERCC1
Tbio
Novelty:  0.00079472
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
3
2
1.6
97.8
autoimmune thyroid disease
3
2
0
1.7
95.6
4
2
0
2
95.2
2
2
0
1.5
94.8
6
2
0
1.4
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.6
97.8
autoimmune thyroid disease
0
1.7
95.6
0
2
95.2
0
1.5
94.8
0
1.4
91.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA cross-link repair 1B
VGNC:6742
469419
Macaque
DNA cross-link repair 1B
707742
Mouse
MGI:2156057
140917
Rat
RGD:1310343
310745
Dog
DNA cross-link repair 1B
VGNC:39807
606778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA cross-link repair 1B
Macaque
DNA cross-link repair 1B
Mouse
Rat
Dog
DNA cross-link repair 1B
Publication Statistics
PubMed Score 19.49
PubMed score by year
PubTator Score 12.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title