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Tbio
DCLRE1A
DNA cross-link repair 1A protein

Protein Summary
Description
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361384
  • ENSP00000355185
  • ENSG00000198924
  • ENST00000369305
  • ENSP00000358311

Symbol
  • KIAA0086
  • SNM1
  • SNM1A
  • PSO2
  • SNM1
  • SNM1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
histone modification site profile
0.66
tissue sample
0.66
transcription factor binding site profile
0.64
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.44   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.44   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
MUS81
Tbio
Family:  Enzyme
Novelty:  0.00532122
Score:  0.981
Data Source:  STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.974
Data Source:  STRINGDB
EME1
Tbio
Family:  Enzyme
Novelty:  0.017415
Score:  0.973
Data Source:  STRINGDB
SLX4
Tbio
Family:  Enzyme
Novelty:  0.01677273
Score:  0.972
Data Source:  STRINGDB
ERCC1
Tbio
Novelty:  0.00079472
Score:  0.967
Data Source:  STRINGDB
FAN1
Tbio
Family:  Enzyme
Novelty:  0.05719629
Score:  0.966
Data Source:  STRINGDB
FANCD2
Tbio
Novelty:  0.00316101
Score:  0.963
Data Source:  STRINGDB
FANCI
Tbio
Novelty:  0.01223788
Score:  0.961
Data Source:  STRINGDB
ERCC4
Tbio
Family:  Enzyme
Novelty:  0.01076913
Score:  0.961
Data Source:  STRINGDB
FAAP24
Tbio
Novelty:  0.08081633
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VII activating protease measurement
1
1
0
281.9
47.6
mathematical ability
1
1
1
1.7
systolic blood pressure
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VII activating protease measurement
0
281.9
47.6
mathematical ability
1
1.7
systolic blood pressure
1
0.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA cross-link repair 1A
VGNC:2473
450747
Macaque
DNA cross-link repair 1A
697882
Mouse
MGI:1930042
55947
Rat
RGD:1306156
292127
Dog
DNA cross-link repair 1A
VGNC:39806
477824
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA cross-link repair 1A
Macaque
DNA cross-link repair 1A
Mouse
Rat
Dog
DNA cross-link repair 1A
Publication Statistics
PubMed Score 117.44
PubMed score by year
PubTator Score 45.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title