Tchem DCLK2 Serine/threonine-protein kinase DCLK2

Protein Summary

Description

Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q8N568
• C9J5Q9
• Q59GC8
• Q8N399

Gene Name

• DCLK2

Ensembl ID

• ENST00000296550
• ENSP00000296550
• ENSG00000170390
• ENST00000302176
• ENSP00000303887
• ENST00000506325
• ENSP00000427235

Symbol

• DCAMKL2
• DCDC3B
• DCK2
• CL2
• DCK2
• CLIK2
• DCDC3
• CLICK2
• DCDC3B
• DCAMKL2
• CLICK-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
molecular function	0.9
small molecule	0.8
tissue sample	0.71
transcription factor	0.63

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Dcamkl Family / Serine/threonine-protein Kinase Dclk2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.73   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.73   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0