Protein Summary
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
- ENST00000299441
- ENSP00000299441
- ENSG00000166341
- CDH19
- CDH25
- FIB1
- KIAA1773
- PCDH16
- FIB1
- MVP2
- CDH19
- CDH25
- CDHR6
- PCDH16
- VMLDS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.65 | ||
histone modification site profile | 0.6 | ||
cell line | 0.58 | ||
disease perturbation | 0.56 | ||
PubMedID | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.74 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 62 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.74 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 62 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (27)
LIX1L
Novelty: 0.5277858
p_int: 0.999448105
p_ni: 0.000551894
p_wrong: 1e-9
Score: 0.45
Data Source: BioPlex,STRINGDB
PPIAL4G
Family: Enzyme
Novelty: 0.93726521
p_int: 0.998616322
p_ni: 0.001383634
p_wrong: 4.4e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
PCDHGA6
Novelty: 1.60910393
p_int: 0.992752496
p_ni: 0.007243426
p_wrong: 0.000004079
Data Source: BioPlex
XAGE1A
Novelty: 0.04421526
p_int: 0.987741203
p_ni: 0.01225879
p_wrong: 7e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
KEGG (1)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Hippo signaling pathway - multiple species | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hippo signaling pathway - multiple species | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (1)
Components (4)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 2 | 2 | 2 | 57.7 | |||||
platelet crit | 1 | 1 | 1 | 40.7 | |||||
mammographic density measurement | 1 | 1 | 1 | 1.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 2 | 57.7 | |||||
platelet crit | 1 | 40.7 | |||||
mammographic density measurement | 1 | 1.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dachsous cadherin-related 1 | 451001 | ||||||
Macaque | dachsous cadherin-related 1 | 711938 | ||||||
Mouse | MGI:2685011 | 233651 | ||||||
Rat | RGD:1309878 | 308912 | ||||||
Dog | dachsous cadherin-related 1 | VGNC:52251 | 476837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dachsous cadherin-related 1 | |||||
Macaque | dachsous cadherin-related 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dachsous cadherin-related 1 | |||||
Publication Statistics
PubMed Score 49.74
PubMed score by year
PubTator Score 29.99
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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