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Tbio
DCHS1
Protocadherin-16

Protein Summary
Description
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299441
  • ENSP00000299441
  • ENSG00000166341

Symbol
  • CDH19
  • CDH25
  • FIB1
  • KIAA1773
  • PCDH16
  • FIB1
  • MVP2
  • CDH19
  • CDH25
  • CDHR6
  • PCDH16
  • VMLDS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
histone modification site profile
0.6
cell line
0.58
disease perturbation
0.56
PubMedID
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.74   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.74   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.99999908
p_ni:  9.2e-7
Data Source:  BioPlex
LIX1L
Tdark
Novelty:  0.5277858
p_int:  0.999448105
p_ni:  0.000551894
p_wrong:  1e-9
Score:  0.45
Data Source:  BioPlex,STRINGDB
PPIAL4G
Tdark
Family:  Enzyme
Novelty:  0.93726521
p_int:  0.998616322
p_ni:  0.001383634
p_wrong:  4.4e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
PCDHGA6
Tdark
Novelty:  1.60910393
p_int:  0.992752496
p_ni:  0.007243426
p_wrong:  0.000004079
Data Source:  BioPlex
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.987741203
p_ni:  0.01225879
p_wrong:  7e-9
Data Source:  BioPlex
DCHS2
Tdark
Novelty:  0.20559245
Score:  0.83
Data Source:  STRINGDB
FJX1
Tbio
Novelty:  0.07957088
Score:  0.792
Data Source:  STRINGDB
USH1C
Tbio
Novelty:  0.01066917
Score:  0.771
Data Source:  STRINGDB
SNX8
Tbio
Novelty:  0.02652492
Score:  0.707
Data Source:  STRINGDB
VANGL2
Tbio
Novelty:  0.00529796
Score:  0.62
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
57.7
platelet crit
1
1
1
40.7
mammographic density measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
57.7
platelet crit
1
40.7
mammographic density measurement
1
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dachsous cadherin-related 1
451001
Macaque
dachsous cadherin-related 1
711938
Mouse
MGI:2685011
233651
Rat
RGD:1309878
308912
Dog
dachsous cadherin-related 1
VGNC:52251
476837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dachsous cadherin-related 1
Macaque
dachsous cadherin-related 1
Mouse
Rat
Dog
dachsous cadherin-related 1
Publication Statistics
PubMed Score 49.74
PubMed score by year
PubTator Score 29.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title