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Tdark
DCAKD
Dephospho-CoA kinase domain-containing protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310604
  • ENSP00000308515
  • ENSG00000172992
  • ENST00000342350
  • ENSP00000341504
  • ENST00000452796
  • ENSP00000413483
  • ENST00000588499
  • ENSP00000467913
  • ENST00000614054
  • ENSP00000478909
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
molecular function
0.88
transcription factor
0.85
transcription factor binding site profile
0.84
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999876963
p_ni:  0.000123037
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.997952978
p_ni:  0.002047022
Score:  0.253
Data Source:  BioPlex,STRINGDB
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
p_int:  0.982928091
p_ni:  0.017071909
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.972103263
p_ni:  0.027896737
Data Source:  BioPlex
TMEM9B
Tdark
Novelty:  0.56628366
p_int:  0.96391082
p_ni:  0.03608918
Data Source:  BioPlex
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.947271494
p_ni:  0.052728506
Data Source:  BioPlex
UST
Tbio
Family:  Enzyme
Novelty:  0.03897672
p_int:  0.944770063
p_ni:  0.055229937
Score:  0.179
Data Source:  BioPlex,STRINGDB
APBB1
Tbio
Novelty:  0.00630564
p_int:  0.931182306
p_ni:  0.068817694
Score:  0.175
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.90070032
p_ni:  0.099299504
p_wrong:  1.76e-7
Data Source:  BioPlex
IL4R
Tclin
Novelty:  0.00359183
p_int:  0.860958489
p_ni:  0.139041511
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
3
90.4
white matter hyperintensity measurement
5
4
4
8.1
88.8
BMI-adjusted hip circumference
1
6
6
86.9
hip circumference
1
3
3
86
heel bone mineral density
2
2
2
84.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
90.4
white matter hyperintensity measurement
4
8.1
88.8
BMI-adjusted hip circumference
6
86.9
hip circumference
3
86
heel bone mineral density
2
84.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dephospho-CoA kinase domain containing
VGNC:12086
468392
Mouse
MGI:1915337
68087
Rat
RGD:1359211
360639
Dog
dephospho-CoA kinase domain containing
VGNC:53204
490930
Horse
dephospho-CoA kinase domain containing
VGNC:49402
100064169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dephospho-CoA kinase domain containing
Mouse
Rat
Dog
dephospho-CoA kinase domain containing
Horse
dephospho-CoA kinase domain containing
Publication Statistics
PubMed Score 0.63
PubMed score by year
PubTator Score 0.13
PubTator score by year
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Related Publications
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PMID
Year
Title