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Tbio
DCAF8
DDB1- and CUL4-associated factor 8

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326837
  • ENSP00000318227
  • ENSG00000132716
  • ENST00000368073
  • ENSP00000357052
  • ENST00000368074
  • ENSP00000357053
  • ENST00000475733
  • ENSP00000476351
  • ENST00000610139
  • ENSP00000477464

Symbol
  • H326
  • WDR42A
  • GAN2
  • H326
  • WDR42A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.85
transcription factor binding site profile
0.83
kinase perturbation
0.76
histone modification site profile
0.71
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.12   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.12   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999925487
p_ni:  0.000074513
Score:  0.934
Data Source:  BioPlex,STRINGDB
PDE7A
Tclin
Family:  Enzyme
Novelty:  0.00872596
p_int:  0.999807889
p_ni:  0.000188461
p_wrong:  0.00000365
Data Source:  BioPlex
METTL8
Tdark
Family:  Enzyme
Novelty:  0.24190691
p_int:  0.999803555
p_ni:  0.00001763
p_wrong:  0.000178815
Data Source:  BioPlex
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
p_int:  0.99976518
p_ni:  0.000234811
p_wrong:  1e-8
Data Source:  BioPlex
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.99969849
p_ni:  0.00030151
Score:  0.946
Data Source:  BioPlex,STRINGDB
FARP1
Tbio
Novelty:  0.04040696
p_int:  0.99886208
p_ni:  0.000625485
p_wrong:  0.000512434
Data Source:  BioPlex
TFB1M
Tbio
Family:  Enzyme
Novelty:  0.0236373
p_int:  0.993006535
p_ni:  0.006993465
Data Source:  BioPlex
DDB1
Tbio
Novelty:  0.00345896
p_int:  0.992833319
p_ni:  0.007166681
Score:  0.966
Data Source:  BioPlex,STRINGDB
ARHGEF26
Tbio
Novelty:  0.09349583
p_int:  0.991068361
p_ni:  0.006707929
p_wrong:  0.00222371
Data Source:  BioPlex
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.987790073
p_ni:  0.012209927
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
3
26.1
FEV/FEC ratio
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
3
26.1
FEV/FEC ratio
1
17.8
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 8.12
PubMed score by year
PubTator Score 9.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title