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Tdark
DCAF5
DDB1- and CUL4-associated factor 5

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341516
  • ENSP00000341351
  • ENSG00000139990
  • ENST00000554215
  • ENSP00000451551
  • ENST00000556847
  • ENSP00000452052
  • ENST00000557386
  • ENSP00000451845

Symbol
  • BCRG2
  • KIAA1824
  • WDR22
  • BCRG2
  • BCRP2
  • WDR22
  • D14S1461E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.8
cell type or tissue
0.78
virus perturbation
0.64
microRNA
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.999982533
p_ni:  0.000017467
Data Source:  BioPlex
RWDD2B
Tdark
Novelty:  0.42452529
p_int:  0.99976461
p_ni:  0.00023539
Data Source:  BioPlex
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.999676696
p_ni:  0.000323304
Data Source:  BioPlex
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.998960515
p_ni:  0.001039485
Data Source:  BioPlex
DLX6
Tbio
Family:  TF
Novelty:  0.01455012
p_int:  0.997011501
p_ni:  0.002988499
Data Source:  BioPlex
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.993744295
p_ni:  0.006255703
p_wrong:  2e-9
Data Source:  BioPlex
TCF25
Tbio
Novelty:  0.08961823
p_int:  0.993408399
p_ni:  0.0065916
Data Source:  BioPlex
ELOA2
Tdark
Family:  Enzyme
Novelty:  0.7420148
p_int:  0.991958628
p_ni:  0.008041372
Data Source:  BioPlex
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
p_int:  0.977753067
p_ni:  0.022246933
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.977606016
p_ni:  0.022393984
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
4
8
98.5
platelet count
4
5
7
18.9
96.7
cognitive function measurement
3
2
3
54.3
neuroticism measurement
5
4
3
5.9
52.7
2
2
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
98.5
platelet count
7
18.9
96.7
cognitive function measurement
3
54.3
neuroticism measurement
3
5.9
52.7
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 5
VGNC:3443
452994
Macaque
DDB1 and CUL4 associated factor 5
714522
Mouse
MGI:2444785
320808
Rat
RGD:1306535
314273
Dog
DDB1 and CUL4 associated factor 5
VGNC:39794
490749
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 5
Macaque
DDB1 and CUL4 associated factor 5
Mouse
Rat
Dog
DDB1 and CUL4 associated factor 5
Publication Statistics
PubMed Score 1.40
PubMed score by year
PubTator Score 0.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title