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Tbio
DCAF4
DDB1- and CUL4-associated factor 4

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358377
  • ENSP00000351147
  • ENSG00000119599
  • ENST00000394234
  • ENSP00000377781
  • ENST00000509153
  • ENSP00000426178
  • ENST00000555042
  • ENSP00000452131

Symbol
  • WDR21
  • WDR21A
  • WDR21
  • WDR21A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
histone modification site profile
0.84
transcription factor perturbation
0.74
disease
0.63
transcription factor
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999999519
p_ni:  4.81e-7
Score:  0.974
Data Source:  BioPlex,STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.999992496
p_ni:  0.000007504
Data Source:  BioPlex
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.999977078
p_ni:  0.000022922
Score:  0.974
Data Source:  BioPlex,STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999929357
p_ni:  0.000070643
Score:  0.985
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999921592
p_ni:  0.000078408
Score:  0.967
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999785837
p_ni:  0.000214163
Score:  0.745
Data Source:  BioPlex,STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.999774038
p_ni:  0.000225962
Score:  0.984
Data Source:  BioPlex,STRINGDB
AP5M1
Tbio
Novelty:  0.00684623
p_int:  0.999770364
p_ni:  0.000229636
Score:  0.219
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.99968755
p_ni:  0.00031245
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999245514
p_ni:  0.000754486
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
81.3
red blood cell density measurement
1
1
1
75.7
hematocrit
2
1
2
66
eosinophil percentage of leukocytes
1
1
1
63.7
eosinophil count
2
1
2
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
81.3
red blood cell density measurement
1
75.7
hematocrit
2
66
eosinophil percentage of leukocytes
1
63.7
eosinophil count
2
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DDB1 and CUL4 associated factor 4
695337
Mouse
MGI:1921078
73828
Rat
RGD:1306241
362762
Horse
DDB1 and CUL4 associated factor 4
100050032
Chicken
DDB1 and CUL4 associated factor 4
CGNC:51933
423253
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DDB1 and CUL4 associated factor 4
Mouse
Rat
Horse
DDB1 and CUL4 associated factor 4
Chicken
DDB1 and CUL4 associated factor 4
Publication Statistics
PubMed Score 5.06
PubMed score by year
PubTator Score 3.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title