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Tdark
DCAF16
DDB1- and CUL4-associated factor 16

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382247
  • ENSP00000371682
  • ENSG00000163257

Symbol
  • C4orf30
  • C4orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
microRNA
0.63
tissue sample
0.62
histone modification site profile
0.56
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
SPIN4
Tchem
Novelty:  0.15502253
p_int:  0.99999024
p_ni:  0.000009759
p_wrong:  1e-9
Data Source:  BioPlex
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.999913226
p_ni:  0.000086362
p_wrong:  4.12e-7
Data Source:  BioPlex
BMP4
Tchem
Novelty:  0.00047387
p_int:  0.999778343
p_ni:  0.000214832
p_wrong:  0.000006825
Score:  0.158
Data Source:  BioPlex,STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  0.999563899
p_ni:  0.000436088
p_wrong:  1.3e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
TCEANC2
Tdark
Novelty:  0.40325323
p_int:  0.999416321
p_ni:  0.000565437
p_wrong:  0.000018242
Data Source:  BioPlex
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.99899093
p_ni:  0.001008778
p_wrong:  2.92e-7
Data Source:  BioPlex
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.998506923
p_ni:  0.001482348
p_wrong:  0.000010728
Data Source:  BioPlex
TGIF2LY
Tdark
Family:  TF
p_int:  0.998506923
p_ni:  0.001482348
p_wrong:  0.000010728
Data Source:  BioPlex
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
p_int:  0.998359488
p_ni:  0.001495942
p_wrong:  0.00014457
Data Source:  BioPlex
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.997783266
p_ni:  0.002215266
p_wrong:  0.000001468
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
6
10
99.1
BMI-adjusted hip circumference
2
11
13
92.5
appendicular lean mass
2
1
2
87.7
birth weight
1
1
1
81.1
intelligence
1
1
0
7.2
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
10
99.1
BMI-adjusted hip circumference
13
92.5
appendicular lean mass
2
87.7
birth weight
1
81.1
intelligence
0
7.2
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 16
VGNC:586
750823
Macaque
DDB1 and CUL4 associated factor 16
722865
Horse
DDB1 and CUL4 associated factor 16
VGNC:17029
100055762
Cow
DDB1 and CUL4 associated factor 16
VGNC:27903
777600
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 16
Macaque
DDB1 and CUL4 associated factor 16
Horse
DDB1 and CUL4 associated factor 16
Cow
DDB1 and CUL4 associated factor 16
Publication Statistics
PubMed Score 3.67
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title