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Tdark
DCAF15
DDB1- and CUL4-associated factor 15

Protein Summary
Description
May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254337
  • ENSP00000254337
  • ENSG00000132017

Symbol
  • C19orf72
  • C19orf72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
histone modification site profile
0.69
disease perturbation
0.62
tissue
0.58
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
ZEB1
Tbio
Family:  TF
Novelty:  0.00085257
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.297
Data Source:  BioPlex,STRINGDB
TJP2
Tbio
Novelty:  0.00446681
p_int:  0.999993542
p_ni:  0.000006458
Score:  0.193
Data Source:  BioPlex,STRINGDB
TGM2
Tchem
Family:  Enzyme
Novelty:  0.0005293
p_int:  0.999986872
p_ni:  0.000013125
p_wrong:  3e-9
Data Source:  BioPlex
RMI1
Tbio
Novelty:  0.01222442
p_int:  0.999938615
p_ni:  0.000056924
p_wrong:  0.000004461
Score:  0.241
Data Source:  BioPlex,STRINGDB
RUFY3
Tbio
Novelty:  0.1517817
p_int:  0.999678435
p_ni:  0.000321565
Score:  0.228
Data Source:  BioPlex,STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.997711174
p_ni:  0.002279756
p_wrong:  0.000009069
Data Source:  BioPlex
BCOR
Tbio
Novelty:  0.05718292
p_int:  0.993081126
p_ni:  0.006918873
Data Source:  BioPlex
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
p_int:  0.978333423
p_ni:  0.021666565
p_wrong:  1.3e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
p_int:  0.964243363
p_ni:  0.035756034
p_wrong:  6.03e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
LMBRD2
Tdark
Novelty:  0.60495132
p_int:  0.96280051
p_ni:  0.03719947
p_wrong:  2e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 27 receptor subunit alpha measurement
1
1
1
78.5
1
1
1
58.3
neutrophil percentage of leukocytes
1
1
1
52.3
lymphocyte count
1
1
1
48
lymphocyte percentage of leukocytes
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 27 receptor subunit alpha measurement
1
78.5
1
58.3
neutrophil percentage of leukocytes
1
52.3
lymphocyte count
1
48
lymphocyte percentage of leukocytes
1
43.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 15
VGNC:2574
469064
Macaque
DDB1 and CUL4 associated factor 15
718509
Mouse
MGI:2684420
212123
Rat
RGD:1304881
304653
Dog
DDB1 and CUL4 associated factor 15
VGNC:39792
484909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 15
Macaque
DDB1 and CUL4 associated factor 15
Mouse
Rat
Dog
DDB1 and CUL4 associated factor 15
Publication Statistics
PubMed Score 9.55
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title