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Tbio
DCAF12
DDB1- and CUL4-associated factor 12

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361264
  • ENSP00000355114
  • ENSG00000198876

Symbol
  • KIAA1892
  • TCC52
  • WDR40A
  • CT102
  • TCC52
  • WDR40A
  • KIAA1892
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
microRNA
0.74
transcription factor binding site profile
0.71
cell type or tissue
0.67
gene perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999999698
p_ni:  3.02e-7
Score:  0.166
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999999109
p_ni:  8.35e-7
p_wrong:  5.5e-8
Data Source:  BioPlex
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.999995291
p_ni:  0.000004707
p_wrong:  2e-9
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.999980088
p_ni:  0.000019912
Score:  0.232
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.999944428
p_ni:  0.000055572
Data Source:  BioPlex
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999938868
p_ni:  0.000061132
Data Source:  BioPlex
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.99988252
p_ni:  0.000051509
p_wrong:  0.000065971
Data Source:  BioPlex
MCMBP
Tbio
Novelty:  0.13330215
p_int:  0.999856937
p_ni:  0.000143063
Score:  0.29
Data Source:  BioPlex,STRINGDB
GOLIM4
Tbio
Novelty:  0.01923513
p_int:  0.999689603
p_ni:  0.000310391
p_wrong:  6e-9
Data Source:  BioPlex
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.980612318
p_ni:  0.019387657
p_wrong:  2.5e-8
Score:  0.58
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
2
5
84
reticulocyte measurement
3
2
3
83.1
monocyte count
1
1
1
79.8
testosterone measurement
5
2
5
78.9
neutrophil percentage of leukocytes
2
2
2
76.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
84
reticulocyte measurement
3
83.1
monocyte count
1
79.8
testosterone measurement
5
78.9
neutrophil percentage of leukocytes
2
76.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 12
VGNC:4671
465052
Macaque
DDB1 and CUL4 associated factor 12
702148
Mouse
MGI:1916220
68970
Dog
DDB1 and CUL4 associated factor 12
VGNC:39790
481584
Horse
DDB1 and CUL4 associated factor 12
VGNC:17027
100068462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 12
Macaque
DDB1 and CUL4 associated factor 12
Mouse
Dog
DDB1 and CUL4 associated factor 12
Horse
DDB1 and CUL4 associated factor 12
Publication Statistics
PubMed Score 6.88
PubMed score by year
PubTator Score 1.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title