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Tbio
DCAF11
DDB1- and CUL4-associated factor 11

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396936
  • ENSP00000380142
  • ENSG00000100897
  • ENST00000396941
  • ENSP00000380146
  • ENST00000446197
  • ENSP00000415556
  • ENST00000559115
  • ENSP00000452898
  • ENST00000642239
  • ENSP00000494282
  • ENSG00000284796
  • ENST00000644566
  • ENSP00000493711
  • ENST00000646524
  • ENSP00000495415
  • ENST00000646568
  • ENSP00000495416

Symbol
  • WDR23
  • GL014
  • WDR23
  • PRO2389
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
disease perturbation
0.9
kinase perturbation
0.81
histone modification site profile
0.77
transcription factor
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999923934
p_ni:  0.000076066
Score:  0.989
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999729309
p_ni:  0.000270691
Score:  0.977
Data Source:  BioPlex,STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.999727015
p_ni:  0.000272985
Score:  0.981
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999686243
p_ni:  0.000313757
Score:  0.971
Data Source:  BioPlex,STRINGDB
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.998773953
p_ni:  0.001226047
Score:  0.975
Data Source:  BioPlex,STRINGDB
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.998642647
p_ni:  0.001357353
Score:  0.982
Data Source:  BioPlex,STRINGDB
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.997570421
p_ni:  0.002429579
Data Source:  BioPlex
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.996724759
p_ni:  0.003275239
p_wrong:  2e-9
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.9962474
p_ni:  0.0037526
Score:  0.434
Data Source:  BioPlex,STRINGDB
DDB1
Tbio
Novelty:  0.00345896
p_int:  0.995521889
p_ni:  0.004478111
Score:  0.984
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
63.4
platelet count
1
1
1
63.4
mean corpuscular volume
2
2
2
62
mean corpuscular volume
2
2
2
62
self reported educational attainment
1
1
1
55.2
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
63.4
platelet count
1
63.4
mean corpuscular volume
2
62
mean corpuscular volume
2
62
self reported educational attainment
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DDB1 and CUL4 associated factor 11
714867
Mouse
MGI:90168
28199
Rat
RGD:1311288
305895
Dog
DDB1 and CUL4 associated factor 11
490621
Horse
DDB1 and CUL4 associated factor 11
100051911
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DDB1 and CUL4 associated factor 11
Mouse
Rat
Dog
DDB1 and CUL4 associated factor 11
Horse
DDB1 and CUL4 associated factor 11
Publication Statistics
PubMed Score 19.28
PubMed score by year
PubTator Score 5.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title