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Tbio
DBNL
Drebrin-like protein

Protein Summary
Description
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440166
  • ENSP00000415173
  • ENSG00000136279
  • ENST00000448521
  • ENSP00000411701
  • ENST00000456905
  • ENSP00000416421
  • ENST00000468694
  • ENSP00000417653
  • ENST00000490734
  • ENSP00000417749
  • ENST00000494774
  • ENSP00000419992

Symbol
  • CMAP
  • SH3P7
  • ABP1
  • HIP55
  • SH3P7
  • HIP-55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
kinase
0.8
biological process
0.78
transcription factor binding site profile
0.75
tissue
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.47   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.47   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (221)
FGD6
Tbio
Novelty:  0.07213159
p_int:  0.999997457
p_ni:  0.000002535
p_wrong:  8e-9
Score:  0.507
Data Source:  BioPlex,STRINGDB
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.9999878
p_ni:  0.0000122
Score:  0.198
Data Source:  BioPlex,STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.999819286
p_ni:  0.000180714
Score:  0.174
Data Source:  BioPlex,STRINGDB
USP20
Tbio
Family:  Enzyme
Novelty:  0.06647037
p_int:  0.99923326
p_ni:  0.000500768
p_wrong:  0.000265973
Score:  0.303
Data Source:  BioPlex,STRINGDB
RBM23
Tbio
Novelty:  0.03769792
p_int:  0.986037629
p_ni:  0.013962339
p_wrong:  3.3e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
ECI2
Tbio
Family:  Enzyme
Novelty:  0.02317646
p_int:  0.960752838
p_ni:  0.039247162
Score:  0.236
Data Source:  BioPlex,STRINGDB
CMAS
Tbio
Family:  Enzyme
Novelty:  0.04295627
p_int:  0.946444153
p_ni:  0.053555847
Score:  0.228
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.776432001
p_ni:  0.223567999
Data Source:  BioPlex
MAP4K1
Tchem
Family:  Kinase
Novelty:  0.02861969
Score:  0.996
Data Source:  STRINGDB
ZAP70
Tchem
Family:  Kinase
Novelty:  0.0011564
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Caspase-mediated cleavage of cytoskeletal proteins
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Caspase-mediated cleavage of cytoskeletal proteins
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
89
triglyceride measurement
4
4
4
88.8
glucose measurement
1
1
1
79.7
sex hormone-binding globulin measurement
3
1
3
58.4
4
2
2
1.1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
89
triglyceride measurement
4
88.8
glucose measurement
1
79.7
sex hormone-binding globulin measurement
3
58.4
2
1.1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
drebrin like
VGNC:7374
463925
Mouse
MGI:700006
13169
Rat
RGD:70941
83527
Dog
drebrin like
607412
Horse
drebrin like
VGNC:17019
100051642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
drebrin like
Mouse
Rat
Dog
drebrin like
Horse
drebrin like
Publication Statistics
PubMed Score 40.47
PubMed score by year
PubTator Score 24.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title