Tbio DBNL Drebrin-like protein

Protein Summary

Description

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Uniprot Accession IDs

• Q9UJU6
• A4D2I9
• B4DDP6
• B4DEM2
• C9J7P1
• P84070
• Q6IAI8
• Q96F30
• Q96K74
• Q9HBN8
• Q9NR72

Gene Name

• DBNL

Ensembl ID

• ENST00000440166
• ENSP00000415173
• ENSG00000136279
• ENST00000448521
• ENSP00000411701
• ENST00000456905
• ENSP00000416421
• ENST00000468694
• ENSP00000417653
• ENST00000490734
• ENSP00000417749
• ENST00000494774
• ENSP00000419992

Symbol

• CMAP
• SH3P7
• ABP1
• HIP55
• SH3P7
• HIP-55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
kinase	0.8
biological process	0.78
transcription factor binding site profile	0.75
tissue	0.74

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Drebrin-like Protein

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Drebrin-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.67   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.67   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0