DBNL
Drebrin-like protein
Protein Summary
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
- ENST00000440166
- ENSP00000415173
- ENSG00000136279
- ENST00000448521
- ENSP00000411701
- ENST00000456905
- ENSP00000416421
- ENST00000468694
- ENSP00000417653
- ENST00000490734
- ENSP00000417749
- ENST00000494774
- ENSP00000419992
- CMAP
- SH3P7
- ABP1
- HIP55
- SH3P7
- HIP-55
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.81 | ||
kinase | 0.8 | ||
biological process | 0.78 | ||
transcription factor binding site profile | 0.75 | ||
tissue | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.47 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.47 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
FGD6
Novelty: 0.07213159
p_int: 0.999997457
p_ni: 0.000002535
p_wrong: 8e-9
Score: 0.507
Data Source: BioPlex,STRINGDB
NEURL4
Novelty: 0.20430708
p_int: 0.9999878
p_ni: 0.0000122
Score: 0.198
Data Source: BioPlex,STRINGDB
HERC2
Family: Enzyme
Novelty: 0.06552683
p_int: 0.999819286
p_ni: 0.000180714
Score: 0.174
Data Source: BioPlex,STRINGDB
USP20
Family: Enzyme
Novelty: 0.06647037
p_int: 0.99923326
p_ni: 0.000500768
p_wrong: 0.000265973
Score: 0.303
Data Source: BioPlex,STRINGDB
RBM23
Novelty: 0.03769792
p_int: 0.986037629
p_ni: 0.013962339
p_wrong: 3.3e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
ECI2
Family: Enzyme
Novelty: 0.02317646
p_int: 0.960752838
p_ni: 0.039247162
Score: 0.236
Data Source: BioPlex,STRINGDB
CMAS
Family: Enzyme
Novelty: 0.04295627
p_int: 0.946444153
p_ni: 0.053555847
Score: 0.228
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (11)
PathwayCommons (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Caspase-mediated cleavage of cytoskeletal proteins | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Caspase-mediated cleavage of cytoskeletal proteins | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (6)
Components (18)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 1 | 2 | 2 | 89 | |||||
triglyceride measurement | 4 | 4 | 4 | 88.8 | |||||
glucose measurement | 1 | 1 | 1 | 79.7 | |||||
sex hormone-binding globulin measurement | 3 | 1 | 3 | 58.4 | |||||
4 | 2 | 2 | 1.1 | 56.2 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
HbA1c measurement | 2 | 89 | |||||
triglyceride measurement | 4 | 88.8 | |||||
glucose measurement | 1 | 79.7 | |||||
sex hormone-binding globulin measurement | 3 | 58.4 | |||||
2 | 1.1 | 56.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | drebrin like | VGNC:7374 | 463925 | |||||
Mouse | MGI:700006 | 13169 | ||||||
Rat | RGD:70941 | 83527 | ||||||
Dog | drebrin like | 607412 | ||||||
Horse | drebrin like | VGNC:17019 | 100051642 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | drebrin like | |||||
Mouse | ||||||
Rat | ||||||
Dog | drebrin like | |||||
Horse | drebrin like | |||||
Publication Statistics
PubMed Score 40.47
PubMed score by year
PubTator Score 24.34
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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