Tbio DBF4 Protein DBF4 homolog A

Protein Summary

Description

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.

Uniprot Accession IDs

• Q9UBU7
• A4D1D8
• A8K954
• O75226
• Q75MS6
• Q75N01
• Q9Y2M6

Gene Name

• DBF4

Ensembl ID

• ENST00000265728
• ENSP00000265728
• ENSG00000006634
• ENST00000413643
• ENSP00000414083

Symbol

• ASK
• DBF4A
• ZDBF1
• ASK
• CHIF
• DBF4A
• ZDBF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
PubMedID	0.83
transcription factor binding site profile	0.78
virus perturbation	0.76
gene perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Protein Dbf4 Homolog A

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Protein Dbf4 Homolog A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.08   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.08   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0