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Tbio
DAZL
Deleted in azoospermia-like

Protein Summary
Description
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250863
  • ENSP00000250863
  • ENSG00000092345
  • ENST00000399444
  • ENSP00000382373

Symbol
  • DAZH
  • DAZL1
  • DAZLA
  • SPGYLA
  • DAZH
  • DAZL1
  • DAZLA
  • SPGYLA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
co-expressed gene
0.65
biological process
0.62
molecular function
0.6
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.41   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.41   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
DAZAP2
Tbio
Novelty:  0.02387823
Score:  0.939
Data Source:  STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
Score:  0.903
Data Source:  STRINGDB
SYCE2
Tbio
Novelty:  0.16889301
Score:  0.901
Data Source:  STRINGDB
STRA8
Tbio
Novelty:  0.00850797
Score:  0.897
Data Source:  STRINGDB
PUM2
Tbio
Novelty:  0.01849765
Score:  0.897
Data Source:  STRINGDB
DDX4
Tbio
Family:  Enzyme
Novelty:  0.00692586
Score:  0.878
Data Source:  STRINGDB
DND1
Tbio
Novelty:  0.0287312
Score:  0.857
Data Source:  STRINGDB
SYCP3
Tbio
Novelty:  0.00443901
Score:  0.853
Data Source:  STRINGDB
NANOS3
Tbio
Novelty:  0.02275038
Score:  0.844
Data Source:  STRINGDB
NANOS2
Tbio
Novelty:  0.01489157
Score:  0.817
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Find Similar Targets
Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ovarian Infertility Genes
WikiPathways
Ovarian Infertility Genes
WikiPathways
Ovarian Infertility Genes
WikiPathways
Ovarian Infertility Genes
WikiPathways
Ovarian Infertility Genes
Name
Explore in Pharos
Explore in Source
Ovarian Infertility Genes
Ovarian Infertility Genes
Ovarian Infertility Genes
Ovarian Infertility Genes
Ovarian Infertility Genes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
1
1
80.2
body height
1
1
1
72.9
response to opioid
1
1
1
15.8
3
1
0
1.2
9.1
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
80.2
body height
1
72.9
response to opioid
1
15.8
0
1.2
9.1
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deleted in azoospermia like
VGNC:7052
460209
Macaque
deleted in azoospermia like
106992263
Mouse
MGI:1342328
13164
Rat
RGD:1591714
680486
Dog
deleted in azoospermia like
477055
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deleted in azoospermia like
Macaque
deleted in azoospermia like
Mouse
Rat
Dog
deleted in azoospermia like
Publication Statistics
PubMed Score 263.41
PubMed score by year
PubTator Score 104.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title