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Tchem
DAPK3
Death-associated protein kinase 3

Protein Summary
Description
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301264
  • ENSP00000301264
  • ENSG00000167657
  • ENST00000545797
  • ENSP00000442973

Symbol
  • ZIPK
  • DLK
  • ZIP
  • ZIPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.96
transcription factor binding site profile
0.86
protein domain
0.85
small molecule
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.06   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.06   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (62)
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.999999916
p_ni:  8.4e-8
Score:  0.307
Data Source:  BioPlex,STRINGDB
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.999999727
p_ni:  2.67e-7
p_wrong:  6e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.999998571
p_ni:  0.000001429
Score:  0.177
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999995779
p_ni:  0.000003052
p_wrong:  0.000001169
Data Source:  BioPlex
TNFRSF8
Tclin
Novelty:  0.00030231
p_int:  0.999897088
p_ni:  0.000102904
p_wrong:  8e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.962053413
p_ni:  0.000316784
p_wrong:  0.037629804
Score:  0.166
Data Source:  BioPlex,STRINGDB
UNC5B
Tbio
Novelty:  0.01474065
Score:  0.933
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.913
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.861
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.859
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
CDK4
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  2
VEGFA
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
VEGFB
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
PGF
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
Pathways (25)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Programmed Cell Death
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
86.7
mean corpuscular volume
1
1
1
86.6
body mass index
2
2
2
83.2
mean reticulocyte volume
1
1
1
83
erythrocyte count
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
86.7
mean corpuscular volume
1
86.6
body mass index
2
83.2
mean reticulocyte volume
1
83
erythrocyte count
1
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
death associated protein kinase 3
VGNC:10979
455594
Macaque
death associated protein kinase 3
714221
Mouse
MGI:1203520
13144
Rat
RGD:621766
64391
Dog
death associated protein kinase 3
VGNC:39771
476745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
death associated protein kinase 3
Macaque
death associated protein kinase 3
Mouse
Rat
Dog
death associated protein kinase 3
Publication Statistics
PubMed Score 77.06
PubMed score by year
PubTator Score 1785.47
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title