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Tchem
DAPK2
Death-associated protein kinase 2

Protein Summary
Description
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261891
  • ENSP00000261891
  • ENSG00000035664
  • ENST00000457488
  • ENSP00000408277
  • ENST00000558069
  • ENSP00000453235
  • ENST00000612884
  • ENSP00000484390

Symbol
  • DRP1
  • DRP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
co-expressed gene
0.91
disease perturbation
0.9
protein domain
0.85
histone modification site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.91   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 564   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.91   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (26)
CALM1
Tclin
Novelty:  0.00308267
Score:  0.958
Data Source:  STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.958
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.958
Data Source:  STRINGDB
UNC5B
Tbio
Novelty:  0.01474065
Score:  0.941
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.922
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.857
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.851
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.83
Data Source:  STRINGDB
DAPK3
Tchem
Family:  Kinase
Novelty:  0.01551494
Score:  0.807
Data Source:  STRINGDB
DAPK1
Tchem
Family:  Kinase
Novelty:  0.0031894
Score:  0.803
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
CDK4
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  2
VEGFA
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
VEGFB
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
PGF
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
Pathways (8)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Programmed Cell Death
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
35
high density lipoprotein cholesterol measurement
1
1
1
17.6
red blood cell distribution width
2
1
2
17.5
1
1
0
1
14.2
BMI-adjusted waist circumference
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
35
high density lipoprotein cholesterol measurement
1
17.6
red blood cell distribution width
2
17.5
0
1
14.2
BMI-adjusted waist circumference
1
5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
death associated protein kinase 2
VGNC:11853
747631
Macaque
death associated protein kinase 2
706421
Mouse
MGI:1341297
13143
Horse
death associated protein kinase 2
VGNC:17007
100066921
Species
Name
OMA
EggNOG
Inparanoid
Chimp
death associated protein kinase 2
Macaque
death associated protein kinase 2
Mouse
Horse
death associated protein kinase 2
Publication Statistics
PubMed Score 48.91
PubMed score by year
PubTator Score 34.40
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title