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Tchem
DAPK1
Death-associated protein kinase 1

Protein Summary
Description
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358077
  • ENSP00000350785
  • ENSG00000196730
  • ENST00000408954
  • ENSP00000386135
  • ENST00000469640
  • ENSP00000418885
  • ENST00000472284
  • ENSP00000417076
  • ENST00000491893
  • ENSP00000419026
  • ENST00000622514
  • ENSP00000484267

Symbol
  • DAPK
  • DAPK
  • ROCO3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.97
biological term
0.87
biological process
0.85
hub protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.04   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.04   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (129)
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.999999945
p_ni:  4.6e-8
p_wrong:  9e-9
Score:  0.385
Data Source:  BioPlex,STRINGDB
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.99721573
p_ni:  0.000204697
p_wrong:  0.002579574
Score:  0.274
Data Source:  BioPlex,STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.98
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.978
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.977
Data Source:  STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.964
Data Source:  STRINGDB
UNC5B
Tbio
Novelty:  0.01474065
Score:  0.962
Data Source:  Reactome,STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.935
Data Source:  STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.927
Data Source:  STRINGDB
HOXB7
Tbio
Family:  TF
Novelty:  0.00765378
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
CDK4
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  2
VEGFA
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
PGF
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
VEGFB
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
Pathways (967)
Apoptosis (R-HSA-109581)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Programmed Cell Death
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
1
1
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
death associated protein kinase 1
VGNC:8812
464571
Macaque
death associated protein kinase 1
694315
Mouse
MGI:1916885
69635
Rat
RGD:1311629
306722
Dog
death associated protein kinase 1
VGNC:39770
484142
Species
Name
OMA
EggNOG
Inparanoid
Chimp
death associated protein kinase 1
Macaque
death associated protein kinase 1
Mouse
Rat
Dog
death associated protein kinase 1
Publication Statistics
PubMed Score 347.04
PubMed score by year
PubTator Score 332.95
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title