Protein Summary
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
- ENST00000228476
- ENSP00000228476
- ENSG00000110887
- DAMOX
- DAAO
- OXDA
- DAMOX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.74 | ||
disease perturbation | 0.74 | ||
molecular function | 0.73 | ||
biological term | 0.6 | ||
tissue sample | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230.8 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 274 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230.8 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 274 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 235
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (235)
Protein-Protein Interactions (136)
NME2
Family: Kinase
Novelty: 0.00257937
p_int: 0.960173906
p_ni: 0.039826094
Data Source: BioPlex
GSTM1
Family: Enzyme
Novelty: 0.00023264
p_int: 0.950067884
p_ni: 0.049843029
p_wrong: 0.000089087
Score: 0.648
Data Source: BioPlex,STRINGDB
KLHL42
Novelty: 0.25822395
p_int: 0.949224839
p_ni: 0.050775161
Score: 0.248
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (5)
KEGG (5)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Glyoxylate metabolism and glycine degradation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Peroxisomal protein import | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Glyoxylate metabolism and glycine degradation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Peroxisomal protein import | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (5)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 2 | 89.4 | |||||
platelet count | 1 | 1 | 1 | 56.4 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 45.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 89.4 | |||||
platelet count | 1 | 56.4 | |||||
serum gamma-glutamyl transferase measurement | 1 | 45.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | D-amino acid oxidase | VGNC:12911 | 743881 | |||||
Macaque | D-amino acid oxidase | 706373 | ||||||
Mouse | MGI:94859 | 13142 | ||||||
Rat | RGD:621138 | 114027 | ||||||
Dog | D-amino acid oxidase | VGNC:39768 | 486317 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | D-amino acid oxidase | |||||
Macaque | D-amino acid oxidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | D-amino acid oxidase | |||||
Publication Statistics
PubMed Score 230.80
PubMed score by year
PubTator Score 479.89
PubTator score by year
Related Publications
Text Mined References (81)
GeneRif Annotations (52)
Items per page:
0 of 0
PMID | Year | Title |
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