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Tchem
DAO
D-amino-acid oxidase

Protein Summary
Description
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228476
  • ENSP00000228476
  • ENSG00000110887

Symbol
  • DAMOX
  • DAAO
  • OXDA
  • DAMOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
disease perturbation
0.74
molecular function
0.73
biological term
0.6
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.8   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.8   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 235
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (235)
CHEMBL4569453
Rendered image for CHEMBL4569453
1H-Indole-2-carboxylic acid
Rendered image for 1H-Indole-2-carboxylic acid
3-hydroxyquinolin-2-one
Rendered image for 3-hydroxyquinolin-2-one
CHEMBL4531065
Rendered image for CHEMBL4531065
US9212147, 15
Rendered image for US9212147, 15
CHEMBL2338803
Rendered image for CHEMBL2338803
Protein-Protein Interactions (136)
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.960173906
p_ni:  0.039826094
Data Source:  BioPlex
GSTM1
Tbio
Family:  Enzyme
Novelty:  0.00023264
p_int:  0.950067884
p_ni:  0.049843029
p_wrong:  0.000089087
Score:  0.648
Data Source:  BioPlex,STRINGDB
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.949224839
p_ni:  0.050775161
Score:  0.248
Data Source:  BioPlex,STRINGDB
L3HYPDH
Tdark
Family:  Enzyme
Novelty:  0.35456591
Score:  0.975
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.974
Data Source:  STRINGDB
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
Score:  0.961
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.957
Data Source:  STRINGDB
CRAT
Tbio
Family:  Enzyme
Novelty:  0.01242609
Score:  0.955
Data Source:  STRINGDB
PAOX
Tchem
Family:  Enzyme
Novelty:  0.00905719
Score:  0.955
Data Source:  STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
89.4
platelet count
1
1
1
56.4
serum gamma-glutamyl transferase measurement
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
89.4
platelet count
1
56.4
serum gamma-glutamyl transferase measurement
1
45.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
D-amino acid oxidase
VGNC:12911
743881
Macaque
D-amino acid oxidase
706373
Mouse
MGI:94859
13142
Rat
RGD:621138
114027
Dog
D-amino acid oxidase
VGNC:39768
486317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
D-amino acid oxidase
Macaque
D-amino acid oxidase
Mouse
Rat
Dog
D-amino acid oxidase
Publication Statistics
PubMed Score 230.80
PubMed score by year
PubTator Score 479.89
PubTator score by year
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Related Publications
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PMID
Year
Title