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Tdark
DALRD3
DALR anticodon-binding domain-containing protein 3

Protein Summary
Description
The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313778
  • ENSP00000323265
  • ENSG00000178149
  • ENST00000341949
  • ENSP00000344989
  • ENST00000441576
  • ENSP00000410623
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor binding site profile
0.82
kinase perturbation
0.81
transcription factor
0.75
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999982991
p_ni:  0.000007595
p_wrong:  0.000009414
Data Source:  BioPlex
GRP
Tbio
Novelty:  0.00034247
p_int:  0.998826424
p_ni:  0.000001164
p_wrong:  0.001172412
Data Source:  BioPlex
LONP1
Tchem
Family:  Enzyme
Novelty:  0.00334137
p_int:  0.983929255
p_ni:  0.016070745
Score:  0.154
Data Source:  BioPlex,STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.9
Data Source:  STRINGDB
YARS
Tchem
Family:  Enzyme
Novelty:  0.00302115
Score:  0.879
Data Source:  STRINGDB
WDR6
Tbio
Novelty:  0.20146637
Score:  0.775
Data Source:  STRINGDB
TESK2
Tchem
Family:  Kinase
Novelty:  0.24376492
Score:  0.743
Data Source:  STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
Score:  0.708
Data Source:  STRINGDB
SLF2
Tbio
Novelty:  0.08944991
Score:  0.695
Data Source:  STRINGDB
POLR1B
Tbio
Family:  Enzyme
Novelty:  0.06955307
Score:  0.683
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1.1
86.6
body fat distribution
2
1
4
81
BMI-adjusted waist-hip ratio
1
1
1
78.1
self reported educational attainment
3
3
3
76.9
HbA1c measurement
1
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1.1
86.6
body fat distribution
4
81
BMI-adjusted waist-hip ratio
1
78.1
self reported educational attainment
3
76.9
HbA1c measurement
2
76.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DALR anticodon binding domain containing 3
708403
Mouse
MGI:1915039
67789
Rat
RGD:1359206
363146
Dog
DALR anticodon binding domain containing 3
VGNC:39766
484772
Horse
DALR anticodon binding domain containing 3 [Source:HGNC Symbol;Acc:HGNC:25536]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DALR anticodon binding domain containing 3
Mouse
Rat
Dog
DALR anticodon binding domain containing 3
Horse
DALR anticodon binding domain containing 3 [Source:HGNC Symbol;Acc:HGNC:25536]
Publication Statistics
PubMed Score 1.65
PubMed score by year
PubTator Score 0.58
PubTator score by year
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Related Publications
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PMID
Year
Title