Protein Summary
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity. (Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class ...more
- ENST00000308775
- ENSP00000312435
- ENSG00000173402
- ENST00000515359
- ENSP00000440705
- ENST00000538711
- ENSP00000438421
- ENST00000539901
- ENSP00000439334
- ENST00000541308
- ENSP00000440590
- ENST00000545947
- ENSP00000442600
- A3a
- DAG
- AGRNR
- 156DAG
- MDDGA9
- MDDGC7
- MDDGC9
- LGMDR16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
biological process | 0.93 | ||
molecular function | 0.9 | ||
kinase perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 600.46 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 337 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 600.46 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 337 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (165)
CEACAM21
Novelty: 0.46116153
p_int: 0.998312301
p_ni: 0.001686187
p_wrong: 0.000001512
Data Source: BioPlex
TNF
Novelty: 0.00001457
p_int: 0.997018043
p_ni: 0.002981832
p_wrong: 1.25e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
TCTN2
Novelty: 0.11617528
p_int: 0.995277091
p_ni: 0.004716987
p_wrong: 0.000005922
Data Source: BioPlex
TMEM106A
Novelty: 0.32470607
p_int: 0.990205169
p_ni: 0.009794792
p_wrong: 3.9e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (27)
Reactome (16)
KEGG (5)
PathwayCommons (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | ||||
Reactome | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | ||||
Reactome | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | ||||
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | ||||
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | ||||
Developmental Biology | ||||
Viral Interactions (0)
Gene Ontology Terms (76)
Functions (10)
Components (31)
Processes (35)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 5 | 4 | 1 | 98.6 | ||||
mathematical ability | 4 | 3 | 4 | 97.2 | |||||
intelligence | 3 | 11 | 5 | 6.6 | 95.1 | ||||
cognitive function measurement | 2 | 2 | 3 | 93.4 | |||||
reticulocyte count | 3 | 2 | 3 | 92.9 | |||||
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 1 | 98.6 | ||||
mathematical ability | 4 | 97.2 | |||||
intelligence | 5 | 6.6 | 95.1 | ||||
cognitive function measurement | 3 | 93.4 | |||||
reticulocyte count | 3 | 92.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dystroglycan 1 | VGNC:6148 | 460372 | |||||
Macaque | dystroglycan 1 | 706179 | ||||||
Mouse | MGI:101864 | 13138 | ||||||
Rat | RGD:621890 | 114489 | ||||||
Dog | dystroglycan 1 | VGNC:39763 | 476623 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dystroglycan 1 | |||||
Macaque | dystroglycan 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dystroglycan 1 | |||||
Publication Statistics
PubMed Score 600.46
PubMed score by year
PubTator Score 282.15
PubTator score by year
Related Publications
Text Mined References (121)
GeneRif Annotations (67)
Items per page:
0 of 0
PMID | Year | Title |
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