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Tbio
DAG1
Dystroglycan

Protein Summary
Description
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity. (Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308775
  • ENSP00000312435
  • ENSG00000173402
  • ENST00000515359
  • ENSP00000440705
  • ENST00000538711
  • ENSP00000438421
  • ENST00000539901
  • ENSP00000439334
  • ENST00000541308
  • ENSP00000440590
  • ENST00000545947
  • ENSP00000442600

Symbol
  • A3a
  • DAG
  • AGRNR
  • 156DAG
  • MDDGA9
  • MDDGC7
  • MDDGC9
  • LGMDR16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.98
biological process
0.93
molecular function
0.9
kinase perturbation
0.88


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 691.29   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 691.29   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0