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Tbio
DACH1
Dachshund homolog 1

Protein Summary
Description
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611519
  • ENSP00000482493
  • ENSG00000276644
  • ENST00000613252
  • ENSP00000482245
  • ENST00000619232
  • ENSP00000482797
  • ENST00000620444
  • ENSP00000481551

Symbol
  • DACH
  • DACH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
transcription factor perturbation
0.94
gene perturbation
0.72
hub protein
0.67
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.75   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.75   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999999989
p_ni:  9e-9
p_wrong:  2e-9
Data Source:  BioPlex
DACH2
Tbio
Novelty:  0.0806643
p_int:  0.99998162
p_ni:  0.00001838
Score:  0.834
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999903167
p_ni:  0.000093874
p_wrong:  0.000002958
Data Source:  BioPlex
FRAT2
Tbio
Novelty:  0.14416149
p_int:  0.999721107
p_ni:  0.000040277
p_wrong:  0.000238616
Data Source:  BioPlex
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
p_int:  0.997459256
p_ni:  0.000124875
p_wrong:  0.002415869
Data Source:  BioPlex
GPSM1
Tbio
Novelty:  0.03510582
p_int:  0.985624095
p_ni:  0.000546771
p_wrong:  0.013829134
Score:  0.691
Data Source:  BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.977075308
p_ni:  0.00031823
p_wrong:  0.022606462
Data Source:  BioPlex
SCOC
Tbio
Novelty:  0.05277646
p_int:  0.93321796
p_ni:  0.001006738
p_wrong:  0.065775302
Score:  0.177
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.915089524
p_ni:  0.072968394
p_wrong:  0.011942082
Score:  0.268
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.903746919
p_ni:  0.000828272
p_wrong:  0.095424809
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
4
6
10.7
93.2
urate measurement
3
3
3
86.6
platelet crit
2
2
2
86.1
blood urea nitrogen measurement
2
2
2
76.7
creatinine measurement
2
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
10.7
93.2
urate measurement
3
86.6
platelet crit
2
86.1
blood urea nitrogen measurement
2
76.7
creatinine measurement
2
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dachshund family transcription factor 1
VGNC:5051
467281
Macaque
dachshund family transcription factor 1
693532
Mouse
MGI:1277991
13134
Horse
dachshund family transcription factor 1
VGNC:16996
100065685
Opossum
dachshund family transcription factor 1
100010972
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dachshund family transcription factor 1
Macaque
dachshund family transcription factor 1
Mouse
Horse
dachshund family transcription factor 1
Opossum
dachshund family transcription factor 1
Publication Statistics
PubMed Score 129.75
PubMed score by year
PubTator Score 48.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title