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Tchem
DAB2IP
Disabled homolog 2-interacting protein

Protein Summary
Description
Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathw ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259371
  • ENSP00000259371
  • ENSG00000136848
  • ENST00000309989
  • ENSP00000310827
  • ENST00000408936
  • ENSP00000386183

Symbol
  • AF9Q34
  • AIP1
  • KIAA1743
  • AIP1
  • AIP-1
  • AF9Q34
  • DIP1/2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
0.97
transcription factor
0.81
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.19   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.19   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 90
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (94)
ANKS1A
Tbio
Novelty:  0.01972212
p_int:  0.999999941
p_ni:  5.7e-8
p_wrong:  1e-9
Score:  0.314
Data Source:  BioPlex,STRINGDB
CLIP1
Tbio
Novelty:  0.00399891
p_int:  0.99994685
p_ni:  0.000046731
p_wrong:  0.000006419
Score:  0.225
Data Source:  BioPlex,STRINGDB
RFPL3
Tbio
Novelty:  0.44520296
p_int:  0.999835042
p_ni:  0.000164958
Score:  0.381
Data Source:  BioPlex,STRINGDB
MCC
Tbio
Novelty:  0.10374312
p_int:  0.994253494
p_ni:  0.005721672
p_wrong:  0.000024834
Score:  0.253
Data Source:  BioPlex,STRINGDB
CD83
Tbio
Novelty:  0.00138653
p_int:  0.957684337
p_ni:  0.042315663
p_wrong:  1e-9
Data Source:  BioPlex
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.927588212
p_ni:  0.072376133
p_wrong:  0.000035654
Data Source:  BioPlex
CGN
Tbio
Novelty:  0.01097394
p_int:  0.923713534
p_ni:  0.076286438
p_wrong:  2.8e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.914305082
p_ni:  0.085694868
p_wrong:  5e-8
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.808421393
p_ni:  0.189717916
p_wrong:  0.001860691
Data Source:  BioPlex
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.759163787
p_ni:  0.238262643
p_wrong:  0.00257357
Score:  0.194
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (102)
Find Similar Targets
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3
3
5.8
90.9
5
4
3
1.1
77.2
mathematical ability
2
1
2
68.6
2
2
0
1.2
61.8
household income
1
3
3
61.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.8
90.9
3
1.1
77.2
mathematical ability
2
68.6
0
1.2
61.8
household income
3
61.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DAB2 interacting protein
VGNC:4669
473037
Macaque
DAB2 interacting protein
699080
Mouse
MGI:1916851
69601
Rat
RGD:621686
192126
Dog
DAB2 interacting protein
VGNC:39760
491356
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DAB2 interacting protein
Macaque
DAB2 interacting protein
Mouse
Rat
Dog
DAB2 interacting protein
Publication Statistics
PubMed Score 101.19
PubMed score by year
PubTator Score 80.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title